Carnosine Attenuates Early Brain Injury Through Its Antioxidative and Anti-apoptotic Effects in a Rat Experimental Subarachnoid Hemorrhage Model
Carnosine Attenuates Early Brain Injury Through Its Antioxidative and Anti-apoptotic Effects in a Rat Experimental Subarachnoid Hemorrhage Model
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肌肽通过其在大鼠实验性蛛网膜下腔出血模型中的抗氧化和抗凋亡作用减轻早期脑损伤
DOI：
10.1007/s10571-014-0106-1
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发表时间：
2014-09
影响因子：
4
通讯作者：
Zhang, Shuai
中科院分区：
文献类型：
--
作者：
Yang, Ming-Feng;Li, Da-Wei;Fang, Jie;Zhang, Shuai
肌肽（β-丙氨酰-L-组氨酸）已被证明在缺血性脑损伤和神经退行性疾病的动物中提供抗氧化和抗凋亡作用。本研究的目的是检查肌肽是否预防大鼠蛛网膜下腔出血（SAH）诱导的早期脑损伤（EBI）。我们发现，肌肽腹腔注射改善神经行为缺陷，减轻脑水肿和血脑屏障通透性，并降低活性氧水平在48小时后SAH大鼠模型。肌肽治疗可增加组织铜/锌超氧化物歧化酶（CuZn-SOD）和谷胱甘肽过氧化物酶（GSH-Px）的酶活性，降低SAH后升高的乳酸脱氢酶（LDH）活性、丙二醛（MDA）、3-硝基酪氨酸（3-NT）、8-羟基脱氧鸟苷（8-OHDG）、白细胞介素（IL）-1β、IL-6和肿瘤坏死因子-α（TNF-α）的浓度。此外，肌肽治疗减弱SAH诱导的小胶质细胞活化和皮质神经元凋亡。这些结果表明，肌肽给药可以在大鼠模型中SAH后的EBI中提供神经保护。
Carnosine (β-alanyl-l-histidine) has been demonstrated to provide antioxidative and anti-apoptotic roles in the animal of ischemic brain injuries and neurodegenerative diseases. The aim of this study was to examine whether carnosine prevents subarachnoid hemorrhage (SAH)-induced early brain injury (EBI) in rats. We found that intraperitoneal administration of carnosine improved neurobehavioral deficits, attenuated brain edema and blood–brain barrier permeability, and decreased reactive oxygen species level at 48 h following SAH in rat models. Carnosine treatment increased tissue copper/zinc superoxide dismutase (CuZn-SOD) and glutathione peroxidase (GSH-Px) enzymatic activities, and reduced post-SAH elevated lactate dehydrogenase (LDH) activity, the concentration of malondialdehyde (MDA), 3-nitrotyrosine (3-NT), 8-hydroxydeoxyguanosine (8-OHDG), interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) in rats. Furthermore, carnosine treatment attenuated SAH-induced microglia activation and cortical neuron apoptosis. These results indicated that administration of carnosine may provide neuroprotection in EBI following SAH in rat models.
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影响因子：
2.5
作者：
Friedrich V;Flores R;Sehba FA
通讯作者：
Sehba FA
DOI：
10.1016/s1043-4526(09)57003-9
发表时间：
2009-01-01
期刊：
ADVANCES IN FOOD AND NUTRITION RESEARCH, VOL 57
影响因子：
--
作者：
Hipkiss, Alan R.
通讯作者：
Hipkiss, Alan R.
DOI：
10.2741/e209
发表时间：
2010-06
期刊：
Frontiers in bioscience
影响因子：
--
作者：
Baoliang Sun;Fa-ping Shen;Qing-jian Wu;Shu-mei Chi;Ming-feng Yang;Hui Yuan;Fang-min Xie;Yan-Bo Zhang;Jun Chen;Feng Zhang
通讯作者：
Baoliang Sun;Fa-ping Shen;Qing-jian Wu;Shu-mei Chi;Ming-feng Yang;Hui Yuan;Fang-min Xie;Yan-Bo Zhang;Jun Chen;Feng Zhang
影响因子：
2.9
作者：
Driver, AS;Kodavanti, PRS;Mundy, WR
通讯作者：
Mundy, WR
肌肽对小鼠皮质下缺血性血管性痴呆的保护作用
影响因子：
5.5
作者：
Ma, Jing;Xiong, Jia-Yan;Chen, Zhong
通讯作者：
Chen, Zhong