PCDH7 as the key gene related to the co-occurrence of sarcopenia and osteoporosis.
PCDH7 as the key gene related to the co-occurrence of sarcopenia and osteoporosis.
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DOI：
10.3389/fgene.2023.1163162
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发表时间：
2023
影响因子：
3.7
通讯作者：
Sun, Guixin
中科院分区：
文献类型：
--
作者：
Liu, Mingchong;Wang, Yongheng;Shi, Wentao;Yang, Chensong;Wang, Qidong;Chen, Jingyao;Li, Jun;Chen, Bingdi;Sun, Guixin
骨质疏松症和骨质疏松症是老年患者的两种退行性疾病，在老龄化社会中已成为严重的健康问题。肌肉和骨骼是运动系统最重要的组成部分，由中胚层和外胚层间充质干细胞分化而来。它们之间的毗邻解剖关系为力学和化学信号提供了基本条件，这可能有助于骨质疏松症和骨质疏松症的共存。识别它们之间潜在的共同串扰基因可能为预防和治疗它们的发展提供新的见解。在这项研究中，使用DEG分析、WGCNA和机器学习算法来识别石棺减少和骨质疏松症的关键串扰基因；然后使用独立的数据集和临床样本来验证这一点。最后确定了4个串扰基因(ARHGEF10、PCDH7、CST6和ROB03)，发现骨质疏松症、骨质疏松症、骨质疏松症和骨质疏松症患者临床标本中PCDH7的基因表达和蛋白水平均显著高于无骨质疏松症和骨质疏松症患者。PCDH7似乎是与骨质疏松症和骨质疏松症的发生有关的关键基因。
Sarcopenia and osteoporosis, two degenerative diseases in older patients, have become severe health problems in aging societies. Muscles and bones, the most important components of the motor system, are derived from mesodermal and ectodermal mesenchymal stem cells. The adjacent anatomical relationship between them provides the basic conditions for mechanical and chemical signals, which may contribute to the co-occurrence of sarcopenia and osteoporosis. Identifying the potential common crosstalk genes between them may provide new insights for preventing and treating their development. In this study, DEG analysis, WGCNA, and machine learning algorithms were used to identify the key crosstalk genes of sarcopenia and osteoporosis; this was then validated using independent datasets and clinical samples. Finally, four crosstalk genes (ARHGEF10, PCDH7, CST6, and ROBO3) were identified, and mRNA expression and protein levels of PCDH7 in clinical samples from patients with sarcopenia, with osteoporosis, and with both sarcopenia and osteoporosis were found to be significantly higher than those from patients without sarcopenia or osteoporosis. PCDH7 seems to be a key gene related to the development of both sarcopenia and osteoporosis.
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作者：
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通讯作者：
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DOI：
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