Invertebrate post-segregation distorters: a new embryo-killing gene.
Invertebrate post-segregation distorters: a new embryo-killing gene.
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DOI：
10.1371/journal.pbio.1001114
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发表时间：
2011-07
期刊：
影响因子：
9.8
通讯作者：
Sinkins SP
中科院分区：
文献类型：
--
作者：
Sinkins SP
由节肢动物的遗传细胞内细菌引起的细胞质不相容性，以及在面粉甲虫中发现的美狄亚元素，都是分离后扭曲的形式，涉及杀死胚胎，以增加继承它们的后代的比例。最近描述的秀丽隐杆线虫的果皮-泽尔元件也使用了这种机制。像美狄亚一样，负责的基因位于核基因组中，但它与细菌共享父系作用模式。现在，peel-1 基因已被证明编码一种由精子传递的强效毒素，并通过相连的 zeel-1 的合子转录来拯救。线虫自体受精的优势产生了自私遗传元素的不寻常分布模式。进一步的种群和功能研究将揭示其进化。该元素还可能具有用于疾病控制的潜力。
Cytoplasmic incompatibility induced by inherited intracellular bacteria of arthropods, and Medea elements found in flour beetles, are both forms of postsegregation distortion involving the killing of embryos in order to increase the ratio of progeny that inherit them. The recently described peel-zeel element of Caenorhabditis elegans also uses this mechanism; like Medea the genes responsible are in the nuclear genome but it shares a paternal mode of action with the bacteria. The peel-1 gene has now been shown to encode a potent toxin that is delivered by sperm, and rescued by zygotic transcription of the linked zeel-1. The predominance of self-fertilization in C. elegans has produced an unusual distribution pattern for a selfish genetic element; further population and functional studies will shed light on its evolution. The element might also have potential for use in disease control.
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