CTIP2 and lipid metabolism: regulation in skin development and associated diseases.
CTIP2 and lipid metabolism: regulation in skin development and associated diseases.
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DOI：
10.1080/14789450.2021.2003707
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发表时间：
2021-11
影响因子：
3.4
通讯作者：
Indra, Arup K.
中科院分区：
文献类型：
--
作者：
Bhattacharya, Nilika;Ganguli-Indra, Gitali;Indra, Arup K.
关键词：
COUP-TF相互作用蛋白2(CTIP2)是一种重要的转录因子，通过表观遗传修饰和与皮肤、免疫和神经系统发育相关的关键基因的转录调控而发挥其调控作用。以前的研究已经证实了CTIP2在皮肤发育和维护中的重要作用，宣传其在表皮渗透屏障(EPB)动态平衡、伤口愈合、炎症性疾病和上皮性肿瘤中的作用。另一方面，脂代谢失调也在多年来确立了其在正常皮肤发育和各种皮肤相关疾病中的独立新兴作用。本文就CTIP2介导的脂代谢调控与EPB动态平衡的改变、伤口愈合延迟、炎症性疾病加重以及肿瘤的促进和进展之间的关系作一综述。在这里，我们讨论了伴随皮肤发育和相关疾病过程的各种内源性脂质和脂蛋白的复杂相互作用，以及与CTIP2介导的脂代谢调节的可能联系。在皮肤形态发生和包括癌症在内的多种皮肤病的背景下，建立CTIP2和脂质代谢变化之间的联系可以帮助我们为有效的治疗干预寻找新的靶点。
COUP-TF INTERACTING PROTEIN 2 (CTIP2) is a crucial transcription factor exhibiting its control through coupled modulation of epigenetic modification and transcriptional regulation of key genes related to skin, immune, and nervous system development. Previous studies have validated the essential role of CTIP2 in skin development and maintenance, propagating its effects in epidermal permeability barrier (EPB) homeostasis, wound healing, inflammatory diseases, and epithelial cancers. Lipid metabolism dysregulation, on the other hand, has also established its independent emerging role over the years in normal skin development and various skin-associated ailments. This review focuses on the relatively unexplored connections between CTIP2-mediated control of lipid metabolism and alteration of EPB homeostasis, delayed wound healing, inflammatory diseases exacerbation, and cancer promotion and progression. Here we have discussed the intricate interplay of various endogenous lipids and lipoproteins accompanying skin development and associated disease processes and the possible link to CTIP2-mediated regulation of lipid metabolism. Establishing the link between CTIP2 and lipid metabolism alterations in the context of skin morphogenesis and diverse types of skin diseases including cancer can help us identify novel targets for effective therapeutic intervention.
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影响因子：
50.3
作者：
Demehri, Shadmehr;Turkoz, Ahu;Kopan, Raphael
通讯作者：
Kopan, Raphael
影响因子：
16.1
作者：
Butler LM;Perone Y;Dehairs J;Lupien LE;de Laat V;Talebi A;Loda M;Kinlaw WB;Swinnen JV
通讯作者：
Swinnen JV
DOI：
10.1111/j.1087-0024.2004.00829.x
发表时间：
2004-01-01
影响因子：
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作者：
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通讯作者：
Carballido, JM
影响因子：
3.7
作者：
Ganguli-Indra G;Wasylyk C;Liang X;Millon R;Leid M;Wasylyk B;Abecassis J;Indra AK
通讯作者：
Indra AK
影响因子：
4.1
作者：
Avram, D;Fields, A;Leid, M
通讯作者：
Leid, M