Immunoreactivity of α‐melanocyte‐stimulating hormone, adrenocorticotrophic hormone and β‐endorphin in cutaneous malignant melanoma and benign melanocytic naevi
Immunoreactivity of α‐melanocyte‐stimulating hormone, adrenocorticotrophic hormone and β‐endorphin in cutaneous malignant melanoma and benign melanocytic naevi
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皮肤恶性黑色素瘤和良性黑素细胞痣中α-黑素细胞刺激激素、促肾上腺皮质激素和β-内啡肽的免疫反应性
DOI：
10.1046/j.1365-2133.1998.02263.x
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发表时间：
1998
影响因子：
10.3
通讯作者：
Ichihashi
中科院分区：
文献类型：
--
作者：
Nagahama;Funasaka;Fernandez‐Frez;Ohashi;Chakraborty;Ueda;Ichihashi
Melanocyte‐stimulating hormone (MSH) has been reported to enhance the experimental metastatic behaviour of melanoma cells in the mouse model. α‐MSH production and MSH receptor (melanocortin 1 receptor gene) expression have been detected in cultured normal human melanocytes and metastasized melanomas. The exact role of MSH in the metastatic behaviour of human melanoma cells is, however, not yet known. To clarify a possible role of proopiomelanocortin (POMC)‐derived peptides, including α‐MSH, in melanoma development and progression, we analysed immunohistochemically the localization of α‐MSH, adrenocorticotrophic hormone (ACTH) and β‐endorphin in various kinds of benign pigmented naevocytic lesions and malignant melanomas. Three of 21 samples of common and dysplastic naevi showed detectable α‐MSH staining in naevus cells, and five and six of 15 samples were weakly positive for ACTH and β‐endorphin staining, respectively. In melanoma samples, 24 of 45, 23 of 39 and 30 of 42 samples showed positive staining with α‐MSH, ACTH and β‐endorphin antibodies, respectively. Furthermore, staining for all three antibodies was noted to be more intense and diffuse in samples of nodular melanoma, vertically growing acral lentiginous melanoma and superficial spreading melanoma as well as metastatic lesions compared with those of naevi. Although it is yet to be determined whether or not this strong staining for POMC‐derived peptides in advanced melanoma cells indicates a role of autocrine or paracrine regulation, our results suggest a possible involvement of POMC gene products in melanoma progression.
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影响因子：
4.8
作者：
I. Suzuki;R. Cone;S. Im;J. Nordlund;Z. Abdel‐Malek
通讯作者：
I. Suzuki;R. Cone;S. Im;J. Nordlund;Z. Abdel‐Malek
影响因子：
56.9
作者：
MOUNTJOY, KG;ROBBINS, LS;CONE, RD
通讯作者：
CONE, RD
小鼠黑色素瘤在无血清培养基中的锚定非依赖性生长依赖于胰岛素或黑素细胞刺激激素。
影响因子：
3.7
作者：
Bregman,MD;AbdelMalek,ZA;MeyskensJr,FL
通讯作者：
MeyskensJr,FL
α-黑素细胞刺激激素对接触性超敏反应和耐受性诱导的影响。
影响因子：
4.6
作者：
Shimizu,T;Streilein,JW
通讯作者：
Streilein,JW