Defensins as anti-inflammatory compounds and mucosal adjuvants.
Defensins as anti-inflammatory compounds and mucosal adjuvants.
复制标题
DOI：
10.2217/fmb.09.104
复制
发表时间：
2010-01
影响因子：
3.1
通讯作者：
Brogden KA
中科院分区：
文献类型：
--
作者：
Kohlgraf KG;Pingel LC;Dietrich DE;Brogden KA
Human neutrophil peptide α-defensins and human β-defensins are small, well-characterized peptides with broad antimicrobial activities. In mixtures with microbial antigens, defensins attenuate proinflammatory cytokine responses by dendritic cells in culture, attenuate proinflammatory cytokine responses in the nasal fluids of exposed mice and enhance antibody responses in the serum of vaccinated mice. Although the exact mechanisms are unknown, defensins first start by binding to microbial antigens and adhesins, often attenuating toxic or inflammatory-inducing capacities. Binding is not generic; it appears to be both defensin-specific and antigen-specific with high affinities. Binding of defensins to antigens may, in turn, alter the interaction of antigens with epithelial cells and antigen-presenting cells attenuating the production of proinflammatory cytokines. The binding of defensins to antigens may also facilitate the delivery of bound antigen to antigen-presenting cells in some cases via specific receptors. These interactions enhance the immunogenicity of the bound antigen in an adjuvant-like fashion. Future research will determine the extent to which defensins can suppress early events in inflammation and enhance systemic antibody responses, a very recent and exciting concept that could be exploited to develop therapeutics to prevent or treat a variety of oral mucosal infections, particularly where inflammation plays a role in the pathogenesis of disease and its long-term sequelae.
登录
查看更多内容
影响因子：
2.9
作者：
Böhling, A;Hagge, SO;Gutsmann, T
通讯作者：
Gutsmann, T
影响因子：
4.4
作者：
Albanesi, Cristina;Fairchild, Heather R.;Howell, Michael D.
通讯作者：
Howell, Michael D.
影响因子：
3.3
作者：
Bissell, J;Joly, S;Guthmiller, JM
通讯作者：
Guthmiller, JM
影响因子：
3.5
作者：
Aldred, PMR;Hollox, EJ;Armour, JAL
通讯作者：
Armour, JAL
影响因子：
12.4
作者：
Claeys, S;de Belder, T;Bachert, C
通讯作者：
Bachert, C