Amplitude of low-frequency oscillations in schizophrenia: a resting state fMRI study.
Amplitude of low-frequency oscillations in schizophrenia: a resting state fMRI study.
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DOI：
10.1016/j.schres.2009.09.030
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发表时间：
2010-03
影响因子：
4.5
通讯作者：
Milham, Michael P.
中科院分区：
文献类型：
--
作者：
Hoptman, Matthew J.;Zuo, Xi-Nian;Butler, Pamela D.;Javitt, Daniel C.;D'Angelo, Debra;Mauro, Cristina J.;Milham, Michael P.
最近，人们对静息态功能磁共振成像（fMRI）作为临床人群强直性脑功能的测量方法产生了极大的兴趣。大多数研究都集中在检查静息态 fMRI 低频振荡 (LFO) 之间的时间相关性。对这些低频振荡幅度的研究很少有报道。在这里，我们使用低频波动幅度 (ALFF) 和分数 ALFF（fALFF；低频的相对幅度）来检查精神分裂症中 LFO 的幅度。 26 名健康对照者和 29 名精神分裂症或分裂情感障碍患者参与了研究。我们的研究结果表明，患者在舌回、左侧楔叶、左侧岛叶/颞上回和右侧尾状核中表现出与所研究的总频带（即 fALFF）成比例的低频幅度降低，而在内侧前额皮质和右侧海马旁回中则表现出 fALFF 增加。患者舌回、楔叶和楔前叶的 ALFF 减少，而左侧海马旁回的 ALFF 增加。这些结果表明精神分裂症患者存在 LFO 异常。进一步讨论了这些异常对精神分裂症症状的影响。
Recently, a great deal of interest has arisen in resting state fMRI as a measure of tonic brain function in clinical populations. Most studies have focused on the examination of temporal correlation between resting state fMRI low-frequency oscillations (LFOs). Studies on the amplitudes of these low-frequency oscillations are rarely reported. Here, we used amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF; the relative amplitude that resides in the low frequencies) to examine the amplitude of LFO in schizophrenia. Twenty-six healthy controls and 29 patients with schizophrenia or schizoaffective disorder participated. Our findings show that patients showed reduced low-frequency amplitude in proportion to the total frequency band investigated (i.e., fALFF) in the lingual gyrus, left cuneus, left insula/superior temporal gyrus, and right caudate and increased fALFF in the medial prefrontal cortex and the right parahippocampal gyrus. ALFF was reduced in patients in the lingual gyrus, cuneus, and precuneus and increased in the left parahippocampal gyrus. These results suggest LFO abnormalities in schizophrenia. The implication of these abnormalities for schizophrenic symptomatology is further discussed.
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