Increased Transglutaminase 2 Expression and Activity in Rodent Models of Obesity/Metabolic Syndrome and Aging.
Increased Transglutaminase 2 Expression and Activity in Rodent Models of Obesity/Metabolic Syndrome and Aging.
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DOI：
10.3389/fphys.2020.560019
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发表时间：
2020
影响因子：
4
通讯作者：
Fanburg BL
中科院分区：
文献类型：
--
作者：
Penumatsa KC;Falcão-Pires I;Leite S;Leite-Moreira A;Bhedi CD;Nasirova S;Ma J;Sutliff RL;Fanburg BL
心脏的舒张功能障碍以及脉管系统和肺的顺应性降低（即，器官组织硬度增加）是肥胖和代谢综合征的已知特征。同样，心脏舒张功能障碍与衰老有关。转氨酶2（TG 2）的升高导致蛋白质交联和胶原蛋白合成增强，并作为组织硬度发展的候选途径参与。考虑到这些观察结果，我们假设TG 2可能在肥胖/代谢综合征的大鼠模型（BMF 1大鼠）和衰老的小鼠模型（即，衰老的SAMP 8小鼠在本文报道的实验中，首次发现TG 2的表达和活性在来自SAMP 1大鼠和SAMP 8小鼠的器官中自发升高。这些观察结果与以下假设一致，即TG 2相关途径可能参与这两种啮齿动物模型中与心脏舒张功能障碍相关的已知组织硬度。潜在的TG 2通路需要更好地与生理功能障碍相关，并可能最终提供新的治疗见解，以改善组织顺应性。
Diastolic dysfunction of the heart and decreased compliance of the vasculature and lungs (i.e., increased organ tissue stiffness) are known features of obesity and the metabolic syndrome. Similarly, cardiac diastolic dysfunction is associated with aging. Elevation of the enzyme transglutaminase 2 (TG2) leads to protein cross-linking and enhanced collagen synthesis and participates as a candidate pathway for development of tissue stiffness. With these observations in mind we hypothesized that TG2 may be elevated in tissues of a rat model of obesity/metabolic syndrome (the ZSF 1 rat) and a mouse model of aging, i.e., the senescent SAMP8 mouse. In the experiments reported here, TG2 expression and activity were found for the first time to be spontaneously elevated in organs from both the ZSF1 rat and the SAMP8 mouse. These observations are consistent with a hypothesis that a TG2-related pathway may participate in the known tissue stiffness associated with cardiac diastolic dysfunction in these two rodent models. The potential TG2 pathway needs better correlation with physiologic dysfunction and may eventually provide novel therapeutic insights to improve tissue compliance.
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DOI：
10.1016/j.trsl.2014.05.001
发表时间：
2014-10
期刊：
Translational research : the journal of laboratory and clinical medicine
影响因子：
--
作者：
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通讯作者：
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影响因子：
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发表时间：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1093/gerona/glx090
发表时间：
2017-11-01
影响因子：
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作者：
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