Extensively hydrolysed casein formula supplemented with Lactobacillus rhamnosus GG maintains hypoallergenic status: randomised double-blind, placebo-controlled crossover trial.
Extensively hydrolysed casein formula supplemented with Lactobacillus rhamnosus GG maintains hypoallergenic status: randomised double-blind, placebo-controlled crossover trial.
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DOI：
10.1136/bmjopen-2011-000637
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发表时间：
2012
期刊：
影响因子：
2.9
通讯作者：
Scalabrin DM
中科院分区：
文献类型：
--
作者：
Muraro A;Hoekstra MO;Meijer Y;Lifschitz C;Wampler JL;Harris C;Scalabrin DM
评价添加鼠李糖乳杆菌GG（LGG）的深度水解（EH）酪蛋白配方的低变应原性。一项前瞻性、随机、双盲、安慰剂对照交叉试验。意大利和荷兰的两个研究中心。有牛奶过敏记录的儿童有资格入选本试验。在严格避免牛奶蛋白和其他疑似食物过敏原的7天期间后，参与者在双盲安慰剂对照食物挑战（DBPCFC）中以随机顺序用具有证明低过敏原性的EH酪蛋白配方（对照，EHF）和具有相同组成的配方（其中LGG以每克粉末108菌落形成单位添加）（EHF-LGG）进行测试。在DBPCFC中没有不良反应后，用EHF-LGG进行开放攻击，然后用相同的配方进行7天的家庭喂养期。DBPCFC期间摄入研究配方奶粉的任何不良反应的临床评估。对于确认牛奶过敏的所有参与者（n=31），DBPCFC和开放性激发被归类为阴性。补充LGG的EH酪蛋白配方奶粉具有低过敏性，可推荐给对牛奶过敏的婴儿和儿童，他们需要替代含有完整牛奶蛋白的配方奶粉。http://ClinicalTrials.gov标识符：NCT 01181297。低过敏性广泛水解（EH）牛奶配方奶粉或氨基酸配方奶粉被推荐用于管理配方奶粉喂养的婴儿的牛奶过敏。虽然鼠李糖乳杆菌GG（LGG）作为膳食益生菌已安全使用超过25年，但补充LGG的EH酪蛋白配方的安全性和低过敏性状态尚未得到证实。 在EH酪蛋白配方奶粉中添加LGG以提供额外的益处不会改变其低过敏性状态。补充LGG的EH配方奶粉可安全用于婴儿和儿童牛奶过敏的管理。根据公认的欧洲儿科胃肠病学和营养学会（ESPGHAN）和美国儿科学会标准，在适当设计的双盲安慰剂对照食物挑战中测试添加LGG的EH配方，以确定低变应原性是本研究的主要优势。一个局限性是我们的发现的潜在的低新奇。由于LGG是最常用的膳食益生菌，因此可以获得LGG作为婴儿和成人独立膳食补充剂的累积安全数据。
To evaluate the hypoallergenicity of an extensively hydrolysed (EH) casein formula supplemented with Lactobacillus rhamnosus GG (LGG). A prospective, randomised, double-blind, placebo-controlled crossover trial. Two study sites in Italy and The Netherlands. Children with documented cow's milk allergy were eligible for inclusion in this trial. After a 7-day period of strict avoidance of cow's milk protein and other suspected food allergens, participants were tested with an EH casein formula with demonstrated hypoallergenicity (control, EHF) and a formula of the same composition with LGG added at 108 colony-forming units per gram powder (EHF-LGG) in randomised order in a double-blind placebo-controlled food challenge (DBPCFC). After absence of adverse reactions in the DBPCFC, an open challenge was performed with EHF-LGG, followed by a 7-day home feeding period with the same formula. Clinical assessment of any adverse reactions to ingestion of study formulae during the DBPCFC. For all participants with confirmed cow's milk allergy (n=31), the DBPCFC and open challenge were classified as negative. The EH casein formula supplemented with LGG is hypoallergenic and can be recommended for infants and children allergic to cow's milk who require an alternative to formulae containing intact cow's milk protein. http://ClinicalTrials.gov Identifier: NCT01181297. Hypoallergenic extensively hydrolysed (EH) cow's milk-based or amino acid-based formulae are recommended for management of cow's milk allergy in formula-fed infants. Although Lactobacillus rhamnosus GG (LGG) has over 25 years of safe use as a dietary probiotic, the safety and hypoallergenic status of EH casein formula supplemented with LGG has not yet been demonstrated. Supplementing the EH casein formula with LGG to provide additional benefits does not change its hypoallergenic status. The LGG-supplemented EH formula can be safely used for management of cow's milk allergy in infants and children. Testing the LGG-supplemented EH formula in a properly designed double-blind placebo-controlled food challenge in accordance with accepted European Society of Pediatric Gastroenterology and Nutrition (ESPGHAN) and American Academy of Pediatrics standards to establish hypoallergenicity is a major strength of this study. One limitation is the potentially low novelty of our finding. Because LGG is the most used dietary probiotic, accumulated safety data for LGG as a stand-alone dietary supplement in infants and adults are available.
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DOI：
10.1016/j.jaci.2010.10.007
发表时间：
2010-12
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
NIAID-Sponsored Expert Panel;Boyce JA;Assa'ad A;Burks AW;Jones SM;Sampson HA;Wood RA;Plaut M;Cooper SF;Fenton MJ;Arshad SH;Bahna SL;Beck LA;Byrd-Bredbenner C;Camargo CA Jr;Eichenfield L;Furuta GT;Hanifin JM;Jones C;Kraft M;Levy BD;Lieberman P;Luccioli S;McCall KM;Schneider LC;Simon RA;Simons FE;Teach SJ;Yawn BP;Schwaninger JM
通讯作者：
Schwaninger JM
影响因子：
14.2
作者：
García-Ara, C;Boyano-Martínez, T;Martín-Esteban, M
通讯作者：
Martín-Esteban, M
影响因子：
14.2
作者：
Majamaa, H;Isolauri, E
通讯作者：
Isolauri, E
影响因子：
3.6
作者：
SCHRANDER, JJP;VANDENBOGAR, JPH;KESTER, ADM
通讯作者：
KESTER, ADM
影响因子：
5.1
作者：
ISOLAURI, E;SUTAS, Y;TURJANMAA, K
通讯作者：
TURJANMAA, K