HIV/neuroAIDS biomarkers.
HIV/neuroAIDS biomarkers.
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DOI：
10.1016/j.pneurobio.2016.04.003
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发表时间：
2017-10
影响因子：
6.7
通讯作者：
He JJ
中科院分区：
文献类型：
--
作者：
Rahimian P;He JJ
HIV感染通常引起神经系统症状，包括认知和运动功能障碍，这些症状被统称为HIV/neuroAIDS。神经心理学评估和临床症状一直是艾滋病毒/神经艾滋病的主要诊断标准，即使是轻度认知和运动障碍，这是联合抗逆转录病毒治疗时代最常见的艾滋病毒/神经艾滋病形式。这些基于表现的评估和症状通常是描述性的，与客观和定量的基于实验室的生物标志物或生物标志物相比，不具有监测疾病诊断、进展和治疗反应的灵敏度和特异性。此外，使用生物标志物比使用神经心理学评估和临床症状更容易确定人口统计学和合并症（如药物滥用、精神疾病、营养缺乏和合并感染）对HIV/neuroAIDS的影响。因此，在过去的二十年里，人们在识别艾滋病毒/神经艾滋病生物标志物方面做出了巨大的努力。随着艾滋病毒感染人群的老龄化以及他们对神经退行性疾病，特别是阿尔茨海默病的易感性增加，对艾滋病毒/神经艾滋病可靠生物标志物的需求预计将增加。目前，三类HIV/neuroAIDS生物标志物正在进行研究，以建立基于实验室的HIV相关神经损伤的客观定义：脑脊液生物标志物，血液生物标志物和神经影像学生物标志物。在这篇综述中，我们将集中在HIV/neuroAIDS生物标志物发现领域的现有知识。
HIV infection often causes neurological symptoms including cognitive and motor dysfunction, which have been collectively termed HIV/neuroAIDS. Neuropsychological assessment and clinical symptoms have been the primary diagnostic criteria for HIV/neuroAIDS, even for the mild cognitive and motor disorder, the most prevalent form of HIV/neuroAIDS in the era of combination antiretroviral therapy. Those performance-based assessments and symptoms are generally descriptive and do not have the sensitivity and specificity to monitor the diagnosis, progression, and treatment response of the disease when compared to objective and quantitative laboratory-based biological markers, or biomarkers. In addition, effects of demographics and comorbidities such as substance abuse, psychiatric disease, nutritional deficiencies, and co-infection on HIV/neuroAIDS could be more readily determined using biomarkers than using neuropsychological assessment and clinical symptoms. Thus, there have been great efforts in identification of HIV/neuroAIDS biomarkers over the past two decades. The need for reliable biomarkers of HIV/neuroAIDS is expected to increase as the HIV-infected population ages and their vulnerability to neurodegenerative diseases, particularly Alzheimer’s disease increases. Currently, three classes of HIV/neuroAIDS biomarkers are being pursued to establish objective laboratory-based definitions of HIV-associated neurologic injury: cerebrospinal fluid biomarkers, blood biomarkers, and neuroimaging biomarkers. In this review, we will focus on the current knowledge in the field of HIV/neuroAIDS biomarker discovery.
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影响因子：
8.8
作者：
Bian S;Hong J;Li Q;Schebelle L;Pollock A;Knauss JL;Garg V;Sun T
通讯作者：
Sun T
DOI：
10.1097/qai.0000000000000532
发表时间：
2015-05-01
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
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作者：
Anderson AM;Harezlak J;Bharti A;Mi D;Taylor MJ;Daar ES;Schifitto G;Zhong J;Alger JR;Brown MS;Singer EJ;Campbell TB;McMahon DD;Buchthal S;Cohen R;Yiannoutsos C;Letendre SL;Navia BA;HIV Neuroimaging Consortium
通讯作者：
HIV Neuroimaging Consortium
影响因子：
3.2
作者：
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通讯作者：
Thompson, Paul M.
DOI：
10.5501/wjv.v4.i3.188
发表时间：
2015-08-12
期刊：
World journal of virology
影响因子：
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作者：
Bujdoso, Raymond;Landgraf, Matthias;Thackray, Alana M
通讯作者：
Thackray, Alana M
影响因子：
9.9
作者：
Brew, BJ;Pemberton, L;Hagberg, L
通讯作者：
Hagberg, L