Magnetic implants in the tongue for assistive technologies: Tests of migration; oromotor function; and tissue response in miniature pigs.
Magnetic implants in the tongue for assistive technologies: Tests of migration; oromotor function; and tissue response in miniature pigs.
复制标题
DOI：
10.1016/j.archoralbio.2017.04.034
复制
发表时间：
2017-09
影响因子：
3
通讯作者：
Ghovanloo M
中科院分区：
文献类型：
--
作者：
Sokoloff AJ;Yang Z;Sargolzaei S;Strait K;Krasnopeyev A;Easley KA;Mimche S;Ghovanloo M
钛磁体舌体植入的不确定生物学后果限制了舌体驱动系统(TDS)的应用，TDS是一种为有严重身体损伤的个人提供的脑-舌-计算机接口。在此，我们描述了在小型猪的舌体大小与人类相似的动物模型上，钛合金植入和移植后的口腔运动功能和舌组织反应。将1.8×6.2 mm钛-MAG示踪剂植入5头尤卡坦小型猪的舌前部。植入后即刻和6天分别拍摄X光片以评估示踪剂的迁移情况。在三只小型猪中，示踪剂在植入后16天被移植。移植后25天，取舌组织进行组织学和免疫组织化学(IHC)标记。在两只小型猪中，在植入12天后，对愈合的组织标志物进行了死后评估。饮料循环率(DCR)的特征是确定手术对口腔运动功能的影响。植入(N=5)或外植体(N=3)均不改变DCR。X线示示踪剂迁移最小(N=4，0~4 mm)。根据组织学和IHC，植入后两周可见坚固的囊膜，纤维化程度有限。移植造成局部纤维化和有限的肌肉重塑。这些发现表明，用于人类辅助技术的钛镁舌前植入物是安全的。
Uncertain biological consequences of titanium-magnet (Ti-mag) tongue implants constrain application of the Tongue Drive System (TDS), a brain-tongue-computer interface for individuals with severe physical impairment. Here we describe oromotor function and tongue tissue response following Ti-Mag implantation and explantation in the miniature pig, an animal model with a tongue similar in size to humans. A 1.8 × 6.2 mm Ti-mag tracer was implanted into the anterior tongue in five Yucatan minipigs. X-rays were taken immediately and >six days after implantation to evaluate tracer migration. In three minipigs, the tracer was explanted >16 days after implantation. Twenty-five days post-explantation, tongue tissue was harvested and processed for histological and immunohistochemical (IHC) markers of healing. In two minipigs tissue markers of healing were evaluated post-mortem following >12 days implantation. Drink cycle rate (DCR) was characterized to determine the impact of procedures on oromotor function. Neither implantation (N=5) nor explantation (N=3) changed DCR. X-rays revealed minimal tracer migration (N=4, 0–4 mm). By histology and IHC a robust capsule was present two weeks post-implantation with limited fibrosis. Explantation produced localized fibrosis and limited muscle remodeling. These findings suggest the safety of Ti-mag anterior tongue implants for assistive technologies in humans.
登录
查看更多内容
影响因子：
2.9
作者：
Liu, Z. J.;Yamamura, B.;Green, J. R.
通讯作者：
Green, J. R.
影响因子：
4
作者：
Huo X;Ghovanloo M
通讯作者：
Ghovanloo M
影响因子：
2.9
作者：
Liu, Z. -J.;Shcherbatyy, V.;Seifi, A.
通讯作者：
Seifi, A.
影响因子：
3.4
作者：
Perkins, Jonathan A.;Shcherbatyy, Volodymyr;Liu, Zi-Jun
通讯作者：
Liu, Zi-Jun
DOI：
10.1002/ar.20699
发表时间：
2008-07-01
影响因子：
2
作者：
Shcherbatyy, Volodymyr;Perkins, Jonathan A.;Liu, Zi-Jun
通讯作者：
Liu, Zi-Jun