Peritumoral plasmacytoid dendritic cells predict a poor prognosis for intrahepatic cholangiocarcinoma after curative resection.
Peritumoral plasmacytoid dendritic cells predict a poor prognosis for intrahepatic cholangiocarcinoma after curative resection.
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瘤周浆细胞样树突状细胞预测肝内胆管癌根治性切除后预后不良
DOI：
10.1186/s12935-020-01676-z
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发表时间：
2020-12-04
影响因子：
5.8
通讯作者：
Zhou SL
中科院分区：
文献类型：
--
作者：
Hu ZQ;Zhou ZJ;Luo CB;Xin HY;Li J;Yu SY;Zhou SL
浆细胞样树突状细胞(PDC)广泛存在于多种原发和转移的人类肿瘤中，但其在肝内胆管细胞癌中的临床意义尚不清楚。为探讨PDCs在肿瘤内和瘤周的分布及其在根治性切除患者中的潜在功能和预后预测价值，应用免疫组织化学方法检测了359例肝内胆管癌瘤内和瘤周组织中PDC标志物BDCA2、CD3、CD4、CD8和Foxp3的表达，并与预后和临床病理因素进行了比较。结果显示，瘤周组织中BDCA2+pDC数量高的患者，糖类抗原19-9和γ-谷氨酰转移酶水平升高，肿瘤较大和较多，肿瘤淋巴结转移分期较晚，血管/胆管侵犯较多，淋巴转移较多，复发机会较大，总生存期较短。PDC数量较多的瘤周组织也显示Foxp3+调节性T细胞浸润增加，这两个因素都被发现是预测复发时间和总生存期的独立因素。相比之下，患者的预后与肿瘤内pDC的存在无关。肿瘤周围的PDC浸润可能预示着免疫耐受的瘤周微环境，并可用来预测肝内胆管癌根治性切除患者的不良预后。本文的在线版本(10.1186/s12935-020-01676-z)包含向授权用户提供的补充材料。
Plasmacytoid dendritic cells (pDCs) are present in various primary and metastatic human neoplasms; however, their clinical significance in intrahepatic cholangiocarcinoma is not clear. To evaluate pDCs’ distributions in and around tumors as well as their potential function and predictive value for prognosis in patients undergoing curative resection, we performed immunohistochemistry to examine the expression of pDC marker BDCA2, and CD3, CD4, CD8 and Foxp3 in intratumoral and peritumoral tissues from 359 patients with intrahepatic cholangiocarcinoma and compared with prognostic and clinicopathologic factors. Results showed that patients with high numbers of BDCA2+ pDCs in peritumoral tissues were more likely to have elevated levels of carbohydrate antigen 19-9 and gamma-glutamyl transferase, larger and more tumors, advanced tumor-node-metastasis staging, more vascular/bile duct invasion, and lymphatic metastasis in association with greater chance of recurrence and shorter overall survival. Peritumoral tissues with larger numbers of pDCs also showed increased Foxp3+ regulatory T cell infiltration, both of which were found to be independent factors for predicting time to recurrence and overall survival. By contrast, patient outcomes were not associated with the presence of intratumoral pDCs. Peritumoral pDC infiltration may indicate an immune tolerogenic peritumor microenvironment and can be used to predict a poor prognosis for patients undergoing curative resection for intrahepatic cholangiocarcinoma. The online version of this article (10.1186/s12935-020-01676-z) contains supplementary material, which is available to authorized users.
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82.9
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