Usefulness of serum unbound free fatty acid levels to predict death early in patients with ST-segment elevation myocardial infarction (from the Thrombolysis In Myocardial Infarction [TIMI] II trial).
Usefulness of serum unbound free fatty acid levels to predict death early in patients with ST-segment elevation myocardial infarction (from the Thrombolysis In Myocardial Infarction [TIMI] II trial).
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DOI：
10.1016/j.amjcard.2013.08.057
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发表时间：
2014-01-15
影响因子：
2.8
通讯作者：
Kleinfeld, Alan M.
中科院分区：
文献类型：
--
作者：
Huber, Andrew H.;Kampf, J. Patrick;Kwan, Thomas;Zhu, Baolong;Adams, Jesse, III;Kleinfeld, Alan M.
循环总游离脂肪酸 (FFA) 在心肌梗塞 (MI) 早期升高，并与死亡率增加相关。我们在心肌梗死溶栓 (TIMI) II 试验中研究了 ST 段抬高型心肌梗死 (STEMI) 患者的血清游离脂肪酸 (FFAu) 水平与死亡率的关系。TIMI II 纳入了胸痛 4 小时内的患者。患者在入组后 1 小时内接受重组组织纤溶酶原激活剂治疗。对 1834 名患者在治疗前基线时获得的血清样本中的 FFAu 浓度进行了评估。FFA 早在住院第一天就是死亡的独立危险因素，并且在超过 3·8 年的随访中持续成为独立危险因素。当调整其他心血管危险因素时，与第一个四分位数相比，第四个四分位的 FFAu 水平仍然是 MI 导致的死亡（风险比，5.0；95% 置信区间，1.9-13.0）、所有心源性死亡（风险比，2.4；置信区间，1.3-4.4）和全因死亡（风险比，1.9，置信区间， 1.2-3.1).女性处于 FFAu 上两个四分位数的可能性是男性的两倍，死亡率大约是男性的两倍。总之，FFA 水平升高是 STEMI 死亡最早的分子生物标志物之一，并且独立于已知影响 STEMI 结局的其他危险因素。
Circulating total free fatty acids (FFA) are elevated early in myocardial infarction (MI) and are associated with an increase in mortality. We investigated the association of serum unbound free fatty acids (FFAu) levels with mortality,in patients presenting with ST elevation myocardial infarction (STEMI) in the Thrombolysis in Myocardial Infarction (TIMI) II trial.TIMI II enrolled patients within 4 hours of chest pain. Patients were treated with recombinant tissue plasminogen activator within 1 hour of enrollment. The concentration of FFAu was evaluated in serum samplesfrom 1834 patients obtained at baseline, before therapy.FFAu was an independent risk factor for death as early as one day of hospitalization and continued to be an independent risk factor for the more than 3·8 years of follow up. When adjusted for other cardiovascular risk factors FFAu levels in the fourth as compared to the first quartile remained an independent risk factor for death due to MI (hazard ratio, 5.0; 95 % confidence interval, 1.9-13.0), to all cardiac death (hazard ratio, 2.4; confidence interval, 1.3-4.4) and to all cause death (hazard ratio, 1.9, confidence interval, 1.2-3.1).Females were twice as likely to be in the upper two FFAu quartiles and had approximately twice the rate of death as males. In conclusion, increased levels of FFAu are one of the earliest molecular biomarkers of mortality in STEMI and are independent of other risk factors known to affect outcomes in STEMI.
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影响因子：
168.9
作者：
GUPTA, DK;JEWITT, DE;OPIE, LH
通讯作者：
OPIE, LH
影响因子：
2.8
作者：
Kleinfeld, AM;Prothro, D;DeMaria, A
通讯作者：
DeMaria, A
影响因子：
39.3
作者：
Pilz, Stefan;Scharnagl, Hubert;Maerz, Winfried
通讯作者：
Maerz, Winfried
DOI：
10.2147/dmso.s37830
发表时间：
2013
期刊：
Diabetes, metabolic syndrome and obesity : targets and therapy
影响因子：
--
作者：
Gruzdeva O;Uchasova E;Dyleva Y;Belik E;Kashtalap V;Barbarash O
通讯作者：
Barbarash O
影响因子：
4.8
作者：
Bhardwaj, Anju;Truong, Quynh A.;Januzzi, James L., Jr.
通讯作者：
Januzzi, James L., Jr.