k-t accelerated aortic 4D flow MRI in under two minutes: Feasibility and impact of resolution, k-space sampling patterns, and respiratory navigator gating on hemodynamic measurements.
k-t accelerated aortic 4D flow MRI in under two minutes: Feasibility and impact of resolution, k-space sampling patterns, and respiratory navigator gating on hemodynamic measurements.
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DOI：
10.1002/mrm.26661
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发表时间：
2018-01
影响因子：
3.3
通讯作者：
Markl M
中科院分区：
文献类型：
--
作者：
Bollache E;Barker AJ;Dolan RS;Carr JC;van Ooij P;Ahmadian R;Powell A;Collins JD;Geiger J;Markl M
To assess the performance of highly accelerated free breathing aortic 4D flow MRI acquired in under 2 minutes compared to conventional respiratory gated 4D flow. Eight k-t accelerated non-gated 4D flow MRI (PEAK GRAPPA, R=5, TRes=67.2ms) using four ky-kz Cartesian sampling patterns (linear, center-out, out-center-out, random) and two spatial resolutions (SRes1=3.5×2.3×2.6mm3, SRes2=4.5×2.3×2.6mm3) were compared in vitro (aortic coarctation flow phantom) and in 10 healthy volunteers, to conventional 4D flow (16mm-navigator acceptance window; R=2; TRes=39.2ms; SRes=3.2×2.3×2.4mm3). The best k-t accelerated approach was further assessed in 10 patients with aortic disease. k-t accelerated in vitro aortic peak flow (Qmax), net flow (Qnet), and peak velocity (Vmax) were lower than conventional 4D flow indices by ≤4.7%, ≤11%, and ≤22%, respectively. In vivo k-t accelerated acquisitions were significantly shorter but showed a trend to lower image quality compared to conventional 4D flow. Hemodynamic indices for linear and out-center-out k-space samplings were in agreement with conventional 4D flow (Qmax≤13%, Qnet≤13%, Vmax≤17%, p>0.05). Aortic 4D flow MRI in under 2 minutes is feasible with moderate underestimation of flow indices. Differences in k-space sampling patterns suggest an opportunity to mitigate image artifacts by an optimal trade-off between scan time, acceleration, and k-space sampling.
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影响因子：
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