Synapse Type-Dependent Expression of Calcium-Permeable AMPA Receptors.
Synapse Type-Dependent Expression of Calcium-Permeable AMPA Receptors.
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DOI:
10.3389/fnsyn.2018.00034
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发表时间:
2018
影响因子:
3.7
通讯作者:
Sjöström PJ
中科院分区:
文献类型:
--
作者:
Lalanne T;Oyrer J;Farrant M;Sjöström PJ
Calcium-permeable (CP) AMPA-type glutamate receptors (AMPARs) are known to mediate synaptic plasticity in several different interneuron (IN) types. Recent evidence suggests that CP-AMPARs are synapse-specifically expressed at excitatory connections onto a subset of IN types in hippocampus and neocortex. For example, CP-AMPARs are found at connections from pyramidal cells (PCs) to basket cells (BCs), but not to Martinotti cells (MCs). This synapse type-specific expression of CP-AMPARs suggests that synaptic dynamics as well as learning rules are differentially implemented in local circuits and has important implications not just in health but also in disease states such as epilepsy.
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