Dual origins of functionally distinct O-LM interneurons revealed by differential 5-HT(3A)R expression.
Dual origins of functionally distinct O-LM interneurons revealed by differential 5-HT(3A)R expression.
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DOI：
10.1038/nn.3538
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发表时间：
2013-11
影响因子：
25
通讯作者：
McBain, Chris J.
中科院分区：
文献类型：
--
作者：
Chittajallu, Ramesh;Craig, Michael T.;McFarland, Ashley;Yuan, Xiaoqing;Geffen, Scott;Tricoire, Ludovic;Erkkila, Brian;Barron, Sean C.;Lopez, Carla M.;Liang, Barry J.;Jeffries, Brian W.;Pelkey, Kenneth A.;McBain, Chris J.
前脑回路依赖于一个相对较小但非常多样化的GABA能中间神经元群体来结合和携带大的主细胞组件，以实现网络同步和节律发生。尽管在皮层中间神经元的高度异质性，一个给定的亚型的成员通常表现出同质的发育起源，神经调节反应的配置文件，形态特征，神经化学签名，和电气功能。在这里，我们报告了一个令人惊讶的分歧之间的海马定向-陷窝moleculare（O-LM）投射中间神经元，迄今被认为是一个同质的细胞群体。对Htr 3a-GFP和Nkx 2 -1-cre：RCE小鼠的免疫细胞化学、解剖学和电生理学联合研究显示，O-LM细胞分解成尾神经节隆起来源的5-HT 3AR表达亚群和内侧神经节隆起来源的5-HT 3AR缺乏亚群。这两个队列差异参与网络振荡与5-HT 3AR-含有O-LM细胞招聘由肾上腺素能紧张。因此，一个看似统一的中间神经元群体的成员可以表现出独特的电路功能和神经调节特性，由不同的发育起源决定。
Forebrain circuits rely upon a relatively small but remarkably diverse population of GABAergic interneurons to bind and entrain large principal cell assemblies for network synchronization and rhythmogenesis. Despite the high degree of heterogeneity across cortical interneurons, members of a given subtype typically exhibit homogeneous developmental origins, neuromodulatory response profiles, morphological characteristics, neurochemical signatures, and electrical features. Here we report a surprising divergence amongst hippocampal oriens-lacunosum moleculare (O-LM) projecting interneurons that have hitherto been considered a homogeneous cell population. Combined immunocytochemical, anatomical, and electrophysiological interrogation of Htr3a-GFP and Nkx2-1-cre:RCE mice revealed that O-LM cells parse into caudal ganglionic eminence-derived 5-HT3AR-expressing, and medial ganglionic eminence- derived 5-HT3AR-lacking subpopulations. These two cohorts differentially participate in network oscillations with 5-HT3AR-containing O-LM cell recruitment dictated by serotonergic tone. Thus, members of a seemingly uniform interneuron population can exhibit unique circuit functions and neuromodulatory properties dictated by disparate developmental origins.
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影响因子：
8.8
作者：
Denaxa M;Kalaitzidou M;Garefalaki A;Achimastou A;Lasrado R;Maes T;Pachnis V
通讯作者：
Pachnis V
DOI：
10.1523/jneurosci.3583-12.2012
发表时间：
2012-12-05
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Close J;Xu H;De Marco García N;Batista-Brito R;Rossignol E;Rudy B;Fishell G
通讯作者：
Fishell G
影响因子：
13.9
作者：
Fishell G;Rudy B
通讯作者：
Rudy B
影响因子：
25
作者：
Madisen L;Zwingman TA;Sunkin SM;Oh SW;Zariwala HA;Gu H;Ng LL;Palmiter RD;Hawrylycz MJ;Jones AR;Lein ES;Zeng H
通讯作者：
Zeng H
影响因子：
34.7
作者：
Ascoli, Giorgio A.;Alonso-Nanclares, Lidia;Anderson, Stewart A.;Barrionuevo, German;Benavides-Piccione, Ruth;Burkhalter, Andreas;Buzsaki, Gyoergy;Cauli, Bruno;DeFelipe, Javier;Fairen, Alfonso;Feldmeyer, Dirk;Fishell, Gord;Fregnac, Yves;Freund, Tamas F.;Gardner, Daniel;Gardner, Esther P.;Goldberg, Jesse H.;Helmstaedter, Moritz;Hestrin, Shaul;Karube, Fuyuki;Kisvarday, Zoltan F.;Lambolez, Bertrand;Lewis, David A.;Marin, Oscar;Markram, Henry;Munoz, Alberto;Packer, Adam;Petersen, Carl C. H.;Rockland, Kathleen S.;Rossier, Jean;Rudy, Bernardo;Somogyi, Peter;Staiger, Jochen F.;Tamas, Gabor;Thomson, Alex M.;Toledo-Rodriguez, Maria;Wang, Yun;West, David C.;Yuste, Rafael
通讯作者：
Yuste, Rafael