Implementing Algorithm-Guided Warfarin Dosing in an Ethnically Diverse Patient Population Using Electronic Health Records and Preemptive CYP2C9 and VKORC1 Genetic Testing.
Implementing Algorithm-Guided Warfarin Dosing in an Ethnically Diverse Patient Population Using Electronic Health Records and Preemptive CYP2C9 and VKORC1 Genetic Testing.
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DOI：
10.1002/cpt.425
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发表时间：
2016-11
影响因子：
6.7
通讯作者：
Scott SA
中科院分区：
文献类型：
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作者：
Obeng AO;Kaszemacher T;Abul-Husn NS;Gottesman O;Vega A;Waite E;Myers K;Cho J;Bottinger EP;Ellis SB;Scott SA
由于报告的临床试验结果不一致以及缺乏包括非白人群体中普遍存在的等位基因的可用算法，药物遗传学指导的华法林给药的实施受到阻碍。然而，目前的证据表明，算法指导的剂量比经验剂量更准确。为了促进多种族算法指导的华法林剂量使用先发制人的基因检测，我们开发了一种策略，该策略考虑了种族的复杂性，并利用电子健康记录作为算法变量和部署床旁剂量建议。
Implementation of pharmacogenetic-guided warfarin dosing has been hindered by inconsistent results from reported clinical trials and a lack of available algorithms that include alleles prevalent in non-white populations. However, current evidence indicates that algorithm-guided dosing is more accurate than empirical dosing. To facilitate multiethnic algorithm-guided warfarin dosing using preemptive genetic testing, we developed a strategy that accounts for the complexity of race and leverages electronic health records for algorithm variables and deploying point-of-care dose recommendations.
影响因子：
6.7
作者：
通讯作者：
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影响因子：
6.7
作者：
Rasmussen-Torvik, L. J.;Stallings, S. C.;Denny, J. C.
通讯作者：
Denny, J. C.
影响因子：
6.7
作者：
通讯作者：
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