Relationship between Tl-201, Tc-99m (Sn) pyrophosphate and F-18 2-deoxyglucose uptake in ischemically injured dog myocardium.
Relationship between Tl-201, Tc-99m (Sn) pyrophosphate and F-18 2-deoxyglucose uptake in ischemically injured dog myocardium.
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缺血性损伤狗心肌中 Tl-201、Tc-99m (Sn) 焦磷酸盐和 F-18 2-脱氧葡萄糖摄取的关系。
DOI：
10.1016/0002-8703(87)90181-5
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发表时间：
1987
影响因子：
4.8
通讯作者：
Phelps,ME
中科院分区：
文献类型：
--
作者：
Sochor,H;Schwaiger,M;Schelbert,HR;Huang,SC;Ellison,D;Hansen,H;Selin,C;Parodi,O;Phelps,ME
我们之前已经证明，通过f -18-2-脱氧葡萄糖（FDG）和正电子断层扫描评估，再灌注心肌中葡萄糖利用的增强可以预测功能恢复。在这项研究中，我们比较了7只狗在冠状动脉球囊闭塞3小时和再灌注20小时后，F-18 FDG与TI-201和Tc-99m （Sn）焦磷酸盐（Tc-99m PPi）作为组织活力的常规标志物的节段性摄取。用微球法测定心肌血流量。根据示踪剂组织浓度、动脉输入功能和血流量计算区域保留分数。采用三苯四氮氯化（TTC）染色和组织学分析评估缺血损伤。24h时，再灌注心肌的血流量比对照组低22% （p< 0.05）。TI-201摄取与血流量呈线性相关（r= 0.92），再灌注心肌的葡萄糖利用率和Tc-99m PPi分别是对照心肌的2.9倍（p< 0.01）和4.7倍（p< 0.05）。Tc-99m PPi的保留分数随着缺血损伤程度的增加而增加，而F-18 FDG的摄取在轻度细胞损伤的节段中最高。因此，在缺血损伤心肌中，TI-201主要反映血流。F-18 FDG作为葡萄糖利用的标志物，可识别缺血损伤但存活的组织。Tc-99m PPi可测定坏死细胞的混合情况。我们的结果表明，双示踪剂方法可能最好地表征可逆和不可逆损伤组织在给定心肌区域的存在和程度。
We have previously demonstrated that enhanced glucose utilization in reperfused myocardium as assessed by F-18-2-deoxyglucose (FDG) and positron tomography predicts functional recovery. In this study, we compared segmental uptake of F-18 FDG with that of TI-201 and Tc-99m (Sn) pyrophosphate (Tc-99m PPi) as conventional markers of tissue viability in seven dogs after a 3-hour intracoronary balloon occlusion and 20 hours of reperfusion. Myocardial blood flow was determined with microspheres. Regional retention fractions were calculated from tracer tissue concentrations, the arterial input function, and blood flow. ischemic injury was assessed by triphenyltetrazolium chloride (TTC) staining and histologic analysis. At 24 hours, blood flow was 22% lower in reperfused than in control myocardium (p< 0.05). Uptake of TI-201 was related linearly to blood flow (r= 0.92), while glucose utilization and Tc-99m PPi were 2.9 (p< 0.01) and 4.7 (p< 0.05) times higher in reperfused than in control myocardium. Retention fractions of Tc-99m PPi increased with the degree of ischemic injury, while F-18 FDG uptake was highest in segments with mild cell injury. Thus, in ischemically injured myocardium, TI-201 primarily reflects blood flow. F-18 FDG as a marker of glucose utilization identifies ischemically injured but viable tissue. The admixture of necrotic cells can be determined with Tc-99m PPi. Our results indicate that a dual tracer approach might best characterize the presence and extent of reversibly and of irreversibly injured tissue in a given myocardial region.
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突发冠状动脉闭塞犬心肌灌注、心肌坏死和锝-99m焦磷酸盐摄取之间的关系
影响因子：
37.8
作者：
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通讯作者：
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影响因子：
24
作者：
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再灌注和非再灌注心肌梗死中铊 201 摄取的差异。
影响因子：
20.1
作者：
Melin,JA;Becker,LC;Bulkley,BH
通讯作者：
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演变中的心肌梗塞的冠状动脉内溶栓。
影响因子：
39.2
作者：
Ganz,W
通讯作者：
Ganz,W
心肌缺血期间线粒体改变与 99mTc 焦磷酸摄取的关系。
DOI：
10.1152/ajpheart.1982.243.2.h268
发表时间：
1982
期刊：
The American journal of physiology
影响因子：
--
作者：
Mukherjee,A;Buja,LM;Kulkarni,P;Nicar,M;Chien,KR;Willerson,JT
通讯作者：
Willerson,JT