Opioid withdrawal syndrome developing after long-term administration of naldemedine
Opioid withdrawal syndrome developing after long-term administration of naldemedine
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长期服用纳尔德米定后出现阿片类药物戒断综合征
DOI：
10.1017/s147895152200044x
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发表时间：
2022
影响因子：
2.2
通讯作者：
Onishi Hideki
中科院分区：
文献类型：
--
作者：
Ishida Mayumi;Uchida Nozomu;Yabuno Akira;Hasegawa Kosei;Mizunuma Naoki;Takahashi Takao;Onishi Hideki
目的阿片类药物的副作用之一是阿片类药物引起的便秘（OIC）。为了解决这种副作用，开发了口服外周μ阿片受体拮抗剂纳尔德米定。由于该药物不能穿过血脑屏障，因此被认为不会导致伴有中枢神经系统症状的阿片类药物戒断综合征（OWS）。 方法本文报道一例癌症患者，在服用纳尔德米定治疗 OIC 4 个月后出现以焦虑和刺激为中心的症状，经仔细检查后诊断为 OWS。 结果该患者为 65 岁女性，因 IB 期子宫内膜癌接受手术 4 年。 以前曾有过这种情况，但 2 年后又出现骨盆复发。使用医用麻醉剂来控制疼痛，但开始使用纳尔德米定来控制随后的便秘。当怀疑与纳尔德米定相关的OWS并停止服用纳尔德米定时，上述症状在两天内消失，此后未观察到复发。结果的意义对于接受纳尔德米定的患者，无论给药周期如何，都需要考虑OWS的可能性，以维持患者的生活质量。
ObjectiveOne of the side effects of opioid administration is opioid-induced constipation (OIC). To address this side effect, the oral peripheral μ opioid receptor antagonist naldemedine was developed. As this drug does not cross the blood–brain barrier, it is thought that it does not lead to opioid withdrawal syndrome (OWS) with central nervous system symptoms.MethodsHere, we report a cancer patient who presented with symptoms centered round anxiety and irritation 4 months after administration of naldemedine for OIC and who was diagnosed with OWS after close investigation.ResultsThe patient was a 65-year-old female who had surgery for stage IB endometrial cancer 4 years previously, but experienced recurrence involving the pelvis 2 years later. Medical narcotics were used to control pain, but naldemedine was started to control subsequent constipation. When naldemedine-related OWS was suspected and the administration of naldemedine discontinued, the above symptoms disappeared within two days, and no recurrence was observed thereafter.Significance of the resultsFor patients receiving naldemedine, it is necessary to consider the possibility of OWS regardless of the period of administration in order to maintain patient quality of life.
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影响因子：
1.2
作者：
Ishii, Koji;Yamashita, Haruna;Hara, Tetsuya
通讯作者：
Hara, Tetsuya
影响因子：
2.8
作者：
Wesson, DR;Ling, W
通讯作者：
Ling, W
纳尔德米定导致无脑转移的晚期宫颈癌患者出现阿片类药物戒断综合征并伴有严重精神症状
影响因子：
2.2
作者：
Ishida Mayumi;Hiraoka Mie;Yaguchi Ayako;Sugano Koji;Adachi Nasako;Itoga Tomoko;Ishiguro Tomohito;Onishi Hideki
通讯作者：
Onishi Hideki
影响因子：
45.3
作者：
Katakami, Nobuyuki;Harada, Toshiyuki;Boku, Narikazu
通讯作者：
Boku, Narikazu
癌症患者静坐不能的患病率出乎意料地高
影响因子：
2.2
作者：
C. Kawanishi;Hideki Onishi;D. Kato;I. Kishida;T. Furuno;M. Wada;Y. Hirayasu
通讯作者：
Y. Hirayasu