Deep-tissue photoacoustic tomography of a genetically encoded near-infrared fluorescent probe.

Deep-tissue photoacoustic tomography of a genetically encoded near-infrared fluorescent probe.
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遗传编码的近红外荧光探针的深组织光声断层扫描。

DOI:
10.1002/anie.201107026
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发表时间:
2012-02-06
影响因子:
16.6
通讯作者:
Verkhusha, Vladislav V.
Verkhusha, Vladislav V.
中科院分区:
化学1区
文献类型:
--
作者:
Filonov, Grigory S.;Krumholz, Arie;Xia, Jun;Yao, Junjie;Wang, Lihong V.;Verkhusha, Vladislav V.

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皮肤深层:近红外荧光蛋白(iRFP)和深部组织光声断层扫描的组合清楚地证明了iRFP优于其他遗传编码探针。在活体动物4 mm深度处获得了令人印象深刻的分辨率(横向280 μm,轴向75 μm),并产生了肿瘤的体积图像(见图像),从而允许空间分辨监测其发展。
Skin‐deep: The combination of a near‐infrared fluorescent protein (iRFP) and deep‐tissue photoacoustic tomography clearly demonstrates the superiority of iRFP over other genetically encoded probes. Impressive resolution (280 μm lateral and 75 μm axial) was obtained at a depth of 4 mm in a live animal, and volumetric images of a tumor were produced (see image), thus allowing the spatially resolved monitoring of its development.
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