Prospects of photoacoustic tomography.
Prospects of photoacoustic tomography.
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DOI：
10.1118/1.3013698
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发表时间：
2008-12
期刊：
影响因子：
3.8
通讯作者：
Wang LV
中科院分区：
文献类型：
--
作者：
Wang LV
商用高分辨率三维光学成像模式，包括共焦显微镜，双光子显微镜和光学相干断层扫描，从根本上影响了生物医学。不幸的是，这样的工具不能穿透生物组织比光学传输平均自由程（皮肤中~1 mm）更深。光声层析成像技术，结合了强光学对比度和高超声分辨率在一个单一的模态，已经突破了这一基本的深度限制。与此同时，射频或微波诱导的热声层析成像正在积极开发，以将联合收割机射频或微波对比度与超声分辨率相结合。在这篇Vision 20/20的文章中，光声层析成像的前景在以下几个方面进行了设想：（1）作为主流技术出现的光吸收的光声显微术，（2）使用光声显微术的黑素瘤检测，（3）光声内窥镜，（4）同时进行的功能和分子光声断层扫描，（5）基因表达的光声断层扫描，（6）用于流量测量的多普勒光声层析成像，（7）氧代谢率的光声层析成像，（8）前哨淋巴结的光声映射，（9）具有共同信号源的体内多尺度光声成像，（10）乳房的同时光声和热声层析成像，（11）脑的光声和热声断层扫描，和（12）低背景热声分子成像。
Commercially available high-resolution 3D optical imaging modalities—including confocal microscopy, two-photon microscopy and optical coherence tomography—have fundamentally impacted biomedicine. Unfortunately, such tools cannot penetrate biological tissue deeper than the optical transport mean free path (~1 mm in the skin). Photoacoustic tomography, which combines strong optical contrast and high ultrasonic resolution in a single modality, has broken through this fundamental depth limitation. In parallel, radiofrequency- or microwave-induced thermoacoustic tomography is being actively developed to combine radiofrequency or microwave contrast with ultrasonic resolution. In this Vision 20/20 article, the prospects of photoacoustic tomography are envisaged in the following aspects: (1) Photoacoustic microscopy of optical absorption emerging as a mainstream technology, (2) melanoma detection using photoacoustic microscopy, (3) photoacoustic endoscopy, (4) simultaneous functional and molecular photoacoustic tomography, (5) photoacoustic tomography of gene expression, (6) Doppler photoacoustic tomography for flow measurement, (7) photoacoustic tomography of metabolic rate of oxygen, (8) photoacoustic mapping of sentinel lymph nodes, (9) multiscale photoacoustic imaging in vivo with common signal origins, (10) simultaneous photoacoustic and thermoacoustic tomography of the breast, (11) photoacoustic and thermoacoustic tomography of the brain, and (12) low-background thermoacoustic molecular imaging.
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