Tidal volume and diaphragm muscle activity in rats with cervical spinal cord injury.
Tidal volume and diaphragm muscle activity in rats with cervical spinal cord injury.
复制标题
脊髓损伤的大鼠潮汐体积和隔膜肌肉活性。
DOI：
10.1589/jpts.27.791
复制
发表时间：
2015-03
影响因子：
--
通讯作者：
Shindo H
中科院分区：
文献类型：
--
作者：
Imagita H;Nishikawa A;Sakata S;Nishii Y;Minematsu A;Moriyama H;Kanemura N;Shindo H
[目的]建立Wistar大鼠颈髓损伤（CSCI）模型，分析CSCI对呼吸功能的影响。[对象] 12周龄雄性Wistar大鼠32只。[方法]在C3 ~ C7节段制作CSCI模型，分别行膈肌呼吸速度描记术和肌电图检查。计算机断层扫描用于确定脊髓损伤的水平。[结果]术后C3水平损伤大鼠潮气量下降至伤前的22.3%左右。此外，在相同的大鼠，脑电活动显着降低。与伤前相比，C5和C7水平的潮气量分别下降至伤前的78.6%和94.1%。[结论] CSCI大鼠接受胸段脊髓神经支配的呼吸肌群瘫痪。因此，膈肌的肌电信号增加。这些结果表明，呼吸功能与CSCI水平之间存在相关性。
[Purpose] The purpose of this study was to make an experimental model of cervical spinal cord injury (CSCI) using Wistar rats, in order to analyze the influence of CSCI on the respiratory function. [Subjects] Thirty-two male 12-week-old Wistar rats were used. [Methods] The CSCI was made at the levels from C3 to C7, and we performed pneumotachography and electromyography (EMG) on the diaphragm. Computed tomography was used to determine the level of spinal cord damage. [Results] After the operation, the tidal volume of the rats with a C3 level injury decreased to approximately 22.3% of its pre-injury value. In addition, in the same rats, the diaphragmatic electromyogram activity decreased remarkably. Compared with before CSCI, the tidal volume decreased to 78.6% of its pre-injury value in CSCI at the C5 level, and it decreased to 94.1% of its pre-injury value in CSCI at the C7 level. [Conclusion] In the rats that sustained a CSCI in this study, the group of respiratory muscles that receive innervation from the thoracic spinal cord was paralyzed. Therefore, the EMG signal of the diaphragm increased. These results demonstrate that there is a relationship between respiratory function and the level of CSCI.
登录
查看更多内容
影响因子：
2.3
作者：
Mantilla, Carlos B.;Seven, Yasin B.;Zhan, Wen-Zhi;Sieck, Gary C.
通讯作者：
Sieck, Gary C.
影响因子：
--
作者：
Kim, Myoung-Kwon;Hwangbo, Gak
通讯作者：
Hwangbo, Gak
影响因子：
3.4
作者：
Vinit, Stephane;Darlot, Fannie;Kastner, Anne
通讯作者：
Kastner, Anne
影响因子：
15.9
作者：
Lane, Michael A.;Fuller, David D.;White, Todd E.;Reier, Paul J.
通讯作者：
Reier, Paul J.
影响因子：
5.3
作者：
Huettemann, Maik;Nantwi, Kwaku D.;Lee, Icksoo;Liu, Jenney;Mohiuddin, Syed;Petrov, Theodor
通讯作者：
Petrov, Theodor