Diaphragm motor unit recruitment in rats.
Diaphragm motor unit recruitment in rats.
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DOI：
10.1016/j.resp.2010.07.001
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发表时间：
2010-08-31
影响因子：
2.3
通讯作者：
Sieck, Gary C.
中科院分区：
文献类型：
--
作者：
Mantilla, Carlos B.;Seven, Yasin B.;Zhan, Wen-Zhi;Sieck, Gary C.
我们假设有相当大的力量储备给横隔肌(DIAM)，以产生维持呼吸所必需的跨横隔压(PDI)。在大鼠中，我们测量了不同呼吸期(呼吸正常、低氧(10%O2)-高碳酸血症(5%CO2))和非呼吸期(由鼻内辣椒素引起的呼吸道阻塞和打喷嚏)时的PDI和DIAM肌电活动。正常呼吸(21±2%)和低氧高碳酸血症(28±4%)时所产生的最大PDI(P<；0.0001)显著低于呼吸道阻塞(63±4%)和打喷嚏时(94±5%)。自发叹息时产生的PDI为Pdimax的62±5%。相对肌电活动(均方根值)与不同呼吸机和非呼吸机行为时PDI的变化相平行(R2=0.78；p<；0.0001)。这些结果支持了我们的假说，即DIAM有相当大的力量储备来完成呼吸行为。DIAM运动单位招募的模型预测，呼吸行为只需要激活耐疲劳的单位。
We hypothesized that considerable force reserve exists for the diaphragm muscle (DIAm) to generate transdiaphragmatic pressures (Pdi) necessary to sustain ventilation. In rats, we measured Pdi and DIAm EMG activity during different ventilatory (eupnea and hypoxia (10% O2) – hypercapnia (5% CO2)) and non-ventilatory (airway occlusion and sneezing induced by intranasal capsaicin) behaviors. Compared to maximum Pdi (Pdimax - generated by bilateral phrenic nerve stimulation), the Pdi generated during eupnea (21±2%) and hypoxia-hypercapnia (28±4%) were significantly less (P<0.0001) than that generated during airway occlusion (63±4%) and sneezing (94±5%). The Pdi generated during spontaneous sighs was 62±5% of Pdimax. Relative DIAm EMG activity (root mean square [RMS] amplitude) paralleled the changes in Pdi during different ventilatory and non-ventilatory behaviors (r2=0.78; p<0.0001). These results support our hypothesis of a considerable force reserve for the DIAm to accomplish ventilatory behaviors. A model for DIAm motor unit recruitment predicted that ventilatory behaviors would require activation of only fatigue resistant units.
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影响因子：
3.3
作者：
Geiger, PC;Cody, MJ;Sieck, GC
通讯作者：
Sieck, GC
影响因子：
3.3
作者：
BOLSER, DC
通讯作者：
BOLSER, DC
影响因子：
3.3
作者：
Geiger, PC;Cody, MJ;Sieck, GC
通讯作者：
Sieck, GC
影响因子：
2.5
作者：
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通讯作者：
BERGER, AJ
影响因子：
3.4
作者：
HAMM, TM;NEMETH, PM;STUART, DG
通讯作者：
STUART, DG