MR-Spectroscopy of GABA and Glutamate/Glutamine Concentrations in Auditory Cortex in Clinical High-Risk for Psychosis Individuals.
MR-Spectroscopy of GABA and Glutamate/Glutamine Concentrations in Auditory Cortex in Clinical High-Risk for Psychosis Individuals.
复制标题
DOI：
10.3389/fpsyt.2022.859322
复制
发表时间：
2022
影响因子：
4.7
通讯作者：
Uhlhaas, Peter J.
中科院分区：
文献类型：
--
作者：
Grent-'t-Jong, Tineke;Gajwani, Ruchika;Gross, Joachim;Gumley, Andrew, I;Lawrie, Stephen M.;Schwannauer, Matthias;Schultze-Lutter, Frauke;Williams, Stephen R.;Uhlhaas, Peter J.
精神病涉及听觉皮层中 GABA 能和谷氨酸能神经传递的变化，这对于理解感觉缺陷和精神病症状可能很重要。然而，目前尚不清楚临床高危精神病（CHR-P）参与者是否存在此类缺陷以及它们是否与临床结果相关。使用磁共振波谱（MEGAPRESS，1H-MRS，3 特斯拉）来估计 CHR-P（n = 99）、CHR-N（临床高风险阴性，n = 32）和 45 名健康对照大样本中听觉皮层的 GABA、谷氨酸和谷氨酸加谷氨酰胺 (Glx) 水平。检查 CHR-P 组代谢物浓度的组间差异以及与临床症状、一般认知和 1 年随访临床和一般功能的关系。结果显示，仅对 Glx 有边缘（p = 0.039）主组效应，但对 GABA 和谷氨酸浓度没有影响，并且仅在左听觉皮层而非右听觉皮层中存在。然而，这种效应未能通过多重比较校正。探索性事后测试显示，与 CHR-N 组相比，CHR-P 组中的 Glx 水平显着降低（p = 0.029，未校正），但与健康对照相比则不然（p = 0.058，未校正）。 Glx 水平与知觉异常和言语紊乱的严重程度相关。然而，在 CHR-P 组中，Glx 水平并不能预测临床或功能结果。因此，本研究的结果表明，MRS 测量的 CHR-P 个体听觉皮层中的 GABA、谷氨酸和 Glx 水平基本上是完整的。
Psychosis involves changes in GABAergic and glutamatergic neurotransmission in auditory cortex that could be important for understanding sensory deficits and symptoms of psychosis. However, it is currently unclear whether such deficits are present in participants at clinical high-risk for psychosis (CHR-P) and whether they are associated with clinical outcomes. Magnetic Resonance Spectroscopy (MEGAPRESS, 1H-MRS at 3 Tesla) was used to estimate GABA, glutamate, and glutamate-plus-glutamine (Glx) levels in auditory cortex in a large sample of CHR-P (n = 99), CHR-N (clinical high-risk negative, n = 32), and 45 healthy controls. Examined were group differences in metabolite concentrations as well as relationships with clinical symptoms, general cognition, and 1-year follow-up clinical and general functioning in the CHR-P group. Results showed a marginal (p = 0.039) main group effect only for Glx, but not for GABA and glutamate concentrations, and only in left, not right, auditory cortex. This effect did not survive multiple comparison correction, however. Exploratory post-hoc tests revealed that there were significantly lower Glx levels (p = 0.029, uncorrected) in the CHR-P compared to the CHR-N group, but not relative to healthy controls (p = 0.058, uncorrected). Glx levels correlated with the severity of perceptual abnormalities and disorganized speech scores. However, in the CHR-P group, Glx levels did not predict clinical or functional outcomes. Accordingly, the findings from the present study suggest that MRS-measured GABA, glutamate and Glx levels in auditory cortex of CHR-P individuals are largely intact.
登录
查看更多内容
影响因子：
10.6
作者：
Erickson MA;Ruffle A;Gold JM
通讯作者：
Gold JM
影响因子：
--
作者：
Klosterkötter, J;Hellmich, M;Schultze-Lutter, F
通讯作者：
Schultze-Lutter, F
影响因子：
4.5
作者：
Atagun, M. I.;Sikoglu, E. M.;Can, S. S.;Karakas-Ugurlu, G.;Ulusoy-Kaymak, S.;Caykoylu, A.;Algin, O.;Phillips, M. L.;Moore, C. M.;Ongur, D.
通讯作者：
Ongur, D.
影响因子：
4.2
作者：
Chung, Yoonho;Alswede, Dana;Cannon, Tyrone D.
通讯作者：
Cannon, Tyrone D.
影响因子：
2.5
作者：
Atagün Mİ;Şıkoğlu EM;Soykan Ç;Serdar Süleyman C;Ulusoy-Kaymak S;Çayköylü A;Algın O;Phillips ML;Öngür D;Moore CM
通讯作者：
Moore CM