Perisylvian GABA levels in schizophrenia and bipolar disorder.
Perisylvian GABA levels in schizophrenia and bipolar disorder.
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DOI：
10.1016/j.neulet.2016.11.051
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发表时间：
2017-01-10
影响因子：
2.5
通讯作者：
Moore CM
中科院分区：
文献类型：
--
作者：
Atagün Mİ;Şıkoğlu EM;Soykan Ç;Serdar Süleyman C;Ulusoy-Kaymak S;Çayköylü A;Algın O;Phillips ML;Öngür D;Moore CM
本研究的目的是利用质子磁共振波谱（1H-MRS）技术测定精神分裂症和双相情感障碍患者大脑外侧裂周皮质GABA水平。将精神分裂症（n=25）、双相I型障碍（BD-I; n=28）和双相II型障碍（BD-II; n=20）患者与健康对照组（n=30）进行比较。使用Siemens 3 Tesla全身扫描仪获得1H-MRS数据，以量化左右侧裂周结构（包括上级颞叶）的GABA水平。右侧外侧裂周GABA值在组间差异显著[χ2=9.62，df：3，p = 0.022]。GABA水平显着高于精神分裂症组与健康对照组相比（p=0.002）。此外，抗精神病药物的氯丙嗪等效剂量与右半球GABA水平相关（r2=0.68，p=0.006，n=33）。与双相情感障碍和健康对照组相比，精神分裂症患者右半球的GABA水平升高。皮层回路兴奋性和抑制性控制的平衡可能与听皮层GABA能功能有直接关系。此外，GABA水平可能会改变大脑区域的利益，精神药物，精神分裂症和双相情感障碍的临床阶段。
The aim of this study is to measure GABA levels of perisylvian cortices in schizophrenia and bipolar disorder patients, using proton magnetic resonance spectroscopy (1H-MRS). Patients with schizophrenia (n=25), bipolar I disorder (BD-I; n=28) and bipolar II disorder (BD-II; n=20) were compared with healthy controls (n=30). 1H-MRS data was acquired using a Siemens 3 Tesla whole body scanner to quantify right and left perisylvian structures’ (including superior temporal lobes) GABA levels. Right perisylvian GABA values differed significantly between groups [χ2=9.62, df: 3, p = 0.022]. GABA levels were significantly higher in the schizophrenia group compared with the healthy control group (p=0.002). Furthermore, Chlorpromazine equivalent doses of antipsychotics correlated with right hemisphere GABA levels (r2=0.68, p=0.006, n=33). GABA levels are elevated in the right hemisphere in patients with schizophrenia in comparison to bipolar disorder and healthy controls. The balance between excitatory and inhibitory controls over the cortical circuits may have direct relationship with GABAergic functions in auditory cortices. In addition, GABA levels may be altered by brain regions of interest, psychotropic medications, and clinical stage in schizophrenia and bipolar disorder.
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作者：
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影响因子：
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