Investigation of Heschl's gyrus and planum temporale in patients with schizophrenia and bipolar disorder: a proton magnetic resonance spectroscopy study.
Investigation of Heschl's gyrus and planum temporale in patients with schizophrenia and bipolar disorder: a proton magnetic resonance spectroscopy study.
复制标题
DOI：
10.1016/j.schres.2014.11.012
复制
发表时间：
2015-02
影响因子：
4.5
通讯作者：
Ongur, D.
中科院分区：
文献类型：
--
作者：
Atagun, M. I.;Sikoglu, E. M.;Can, S. S.;Karakas-Ugurlu, G.;Ulusoy-Kaymak, S.;Caykoylu, A.;Algin, O.;Phillips, M. L.;Moore, C. M.;Ongur, D.
关键词：
高级颞叶皮质包括专门负责听觉处理的大脑区域，有几条证据表明，精神分裂症和双相情感障碍在这个大脑区域内都存在结构和功能异常。然而，该区域内可能存在的谷氨酸能功能障碍尚未在成人患者中进行研究。其中精神分裂症患者30例，年龄(38.67±12.46)岁，双相I型精神障碍患者28例，年龄(35.32±9.12)岁，健康对照组30例。使用3.0T西门子Magnetom TIM Trio磁共振系统和单体素分辨波谱序列(PRESS)获取质子磁共振波谱数据，以量化左右Heschl‘s回和颞叶上皮质平面内的脑代谢产物。左侧颞叶上皮质谷氨酸(Glu)(F(2，78)=8.5 2，p<；0.0001)、正乙酰天冬氨酸(T NAA)(F(2，81)=5.73，p=0.005)、肌酸(Tcr)(F(2，83)=5.91，p=0.004)和肌醇(Ins)(F(2，82)=8.49，p<；0.0001)含量显著异常。一般来说，与健康参与者相比，双相情感障碍患者的代谢物水平较低。此外，与精神分裂症患者相比，双相情感障碍患者的TCR和INS浓度显著降低。此外，我们还发现上颞叶皮质代谢产物与临床指标之间存在显著的相关性。由于左脑听觉皮质与语言和言语有关，左半球特有的异常可能具有临床意义。我们的发现提示在精神分裂症和双相情感障碍中有共同的谷氨酸能异常。
Superior temporal cortices include brain regions dedicated to auditory processing and several lines of evidence suggest structural and functional abnormalities in both schizophrenia and bipolar disorder within this brain region. However, possible glutamatergic dysfunction within this region has not been investigated in adult patients. Thirty patients with schizophrenia (38.67 ± 12.46 years of age), 28 euthymic patients with bipolar I disorder (35.32 ± 9.12 years of age), and 30 age-, gender- and education- matched healthy controls were enrolled. Proton Magnetic Resonance Spectroscopy data were acquired using a 3.0T Siemens MAGNETOM TIM Trio MR system and single voxel Point REsolved Spectroscopy Sequence (PRESS) in order to quantify brain metabolites within the left and right Heschl's Gyrus and Planum Temporale of superior temporal cortices. There were significant abnormalities in Glutamate (Glu) (F(2,78)=8.52, p<0.0001), n-Acetyl Aspartate (tNAA) (F(2,81)=5.73, p=0.005), Creatine (tCr) (F(2,83)=5.91, p=0.004) and Inositol (Ins) (F(2,82)=8.49, p<0.0001) concentrations in the left superior temporal cortex. In general, metabolite levels were lower for bipolar disorder patients when compared to healthy participants. Moreover, patients with bipolar disorder exhibited significantly lower tCr and Ins concentrations when compared to schizophrenia patients. In addition, we have found significant correlations between the superior temporal cortex metabolites and clinical measures. As the left auditory cortices are associated with language and speech, left hemisphere specific abnormalities may have clinical significance. Our findings are suggestive of shared glutamatergic abnormalities in schizophrenia and bipolar disorder.
登录
查看更多内容
影响因子：
17.7
作者：
Jardri, Renaud;Pouchet, Alexandre;Thomas, Pierre
通讯作者：
Thomas, Pierre
影响因子：
3.7
作者：
Atagun, M. I.;Guntekin, B.;Basar, E.
通讯作者：
Basar, E.
影响因子：
10.6
作者：
Ethridge, Lauren E.;Hamm, Jordan P.;Shapiro, John R.;Summerfelt, Ann T.;Keedy, Sarah K.;Stevens, Michael C.;Pearlson, Godfrey;Tamminga, Carol A.;Boutros, Nash N.;Sweeney, John A.;Keshavan, Matcheri S.;Thaker, Gunvant;Clementz, Brett A.
通讯作者：
Clementz, Brett A.
影响因子：
10.6
作者：
Auer, DP;Pütz, B;Holsboer, F
通讯作者：
Holsboer, F
影响因子：
5.7
作者：
Homan, Philipp;Vermathen, Peter;Kreis, Roland
通讯作者：
Kreis, Roland