Venous thromboembolism and prognosis in cancer.

Venous thromboembolism and prognosis in cancer.
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DOI:
10.1016/j.thromres.2009.12.023
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发表时间:
2010-06
影响因子:
7.5
通讯作者:
Khorana AA
Khorana AA
中科院分区:
医学3区
文献类型:
--
作者:
Khorana AA

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静脉血栓栓塞(VTE)是恶性肿瘤的常见并发症,近年来其发病率显著增加。静脉血栓栓塞本身可直接导致患者死亡,是癌症患者死亡的第二大原因。此外,新出现的数据表明,恶性肿瘤中凝血的激活与肿瘤生物学,特别是血管生成,是整体相关的。临床高凝状态的发展也与癌症患者的不良预后有关,包括接受全身化疗的患者。这篇综述的重点是临床证据证明静脉血栓栓塞与癌症患者不良的短期和长期预后之间的联系。
Venous thromboembolism (VTE) is a frequent complication of malignancy, and its incidence has increased markedly in recent years. VTE itself can directly lead to patient mortality, and is the second leading cause of death in patients with cancer. Furthermore, emerging data suggest that activation of coagulation in malignancy is integrally linked with tumor biology, particularly with angiogenesis. The development of the clinical hypercoagulable state is also linked with adverse prognosis in patients with cancer, including patients receiving systemic chemotherapy. This review focuses on the clinical evidence documenting a link between VTE and adverse short-term and long-term prognosis in patients with cancer.
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