Postpartum group a Streptococcus sepsis and maternal immunology.
Postpartum group a Streptococcus sepsis and maternal immunology.
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DOI：
10.1111/j.1600-0897.2011.01083.x
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发表时间：
2012-02
期刊：
影响因子：
--
通讯作者：
Aronoff DM
中科院分区：
文献类型：
--
作者：
Mason KL;Aronoff DM
A组链球菌(GAS)是产后感染和败血症的重要病原体。洗手和医院卫生的改善大大降低了产后败血症的发生率，但最近产后气体感染的发生率和严重程度一直在上升，原因不明。几种流行病学、宿主和微生物因素导致产后妇女发生GAS感染和死亡的风险。这些因素包括分娩方式(阴道与剖腹产)、分娩和分娩的地点、接触气体携带者、与怀孕相关的免疫状态变化、宿主的遗传背景、感染气体菌株的毒力以及与女性生殖道组织和器官相关的高度特异性免疫反应。这篇综述将讨论导致产后对GAS易感性增加的复杂因素，以及最近观察到的发病率和死亡率增加的潜在原因。
Group A Streptococcus (GAS) is an historically important agent of puerperal infections and sepsis. The inception of hand-washing and improved hospital hygiene drastically reduced the incidence of puerperal sepsis, but recently the incidence and severity of postpartum GAS infections has been rising for uncertain reasons. Several epidemiological, host, and microbial factors contribute to the risk for GAS infection and mortality in postpartum women. These include the mode of delivery (vaginal vs. caesarean section), the location where labor and delivery occurred, exposure to GAS carriers, the altered immune status associated with pregnancy, the genetic background of the host, the virulence of the infecting GAS strain, and highly specialized immune responses associated with female reproductive tract tissues and organs. This review will discuss the complicated factors that contribute to the increased susceptibility to GAS after delivery and potential reasons for the recent increase observed in morbidity and mortality.
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影响因子：
3.1
作者：
CLEARY, PP;PRAHBU, U;HANDLEY, J
通讯作者：
HANDLEY, J
影响因子：
3.1
作者：
Chatellier, S;Ihendyane, N;Kotb, M
通讯作者：
Kotb, M
影响因子：
4.4
作者：
Aronoff, David M.;Hao, Yibai;Peters-Golden, Marc
通讯作者：
Peters-Golden, Marc
DOI：
10.1016/0002-9378(87)90070-6
发表时间：
1987-03-01
影响因子：
9.8
作者：
BENNETT, PR;ROSE, MP;ELDER, MG
通讯作者：
ELDER, MG
影响因子：
11.8
作者：
Aziz, Ramy K.;Kotb, Malak
通讯作者：
Kotb, Malak