Bone marrow mesenchymal stem cells promote head and neck cancer progression through Periostin-mediated phosphoinositide 3-kinase/Akt/mammalian target of rapamycin.
Bone marrow mesenchymal stem cells promote head and neck cancer progression through Periostin-mediated phosphoinositide 3-kinase/Akt/mammalian target of rapamycin.
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DOI：
10.1111/cas.13479
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发表时间：
2018-03
期刊：
影响因子：
5.7
通讯作者：
Wang H
中科院分区：
文献类型：
--
作者：
Liu C;Feng X;Wang B;Wang X;Wang C;Yu M;Cao G;Wang H
骨髓间充质干细胞（BMMSC）已被证明可以招募到肿瘤微环境中，并在多种癌症中发挥促肿瘤作用。然而，与BMMSC对头颈癌（HNC）的促肿瘤作用相关的分子机制尚不清楚。在这项研究中，我们研究了骨膜蛋白（POSTIN）及其在BMMSC对HNC的促肿瘤作用中的作用。对在BMMSC条件培养基（MSC-CM）中培养的HNC细胞的体外分析表明，MSC-CM通过增强细胞增殖、迁移、上皮-间质转化（EMT）、改变细胞周期调节蛋白的表达和抑制细胞凋亡，显著促进癌症进展。此外，MSC-CM促进POT 3的表达，POT 3通过激活磷酸肌醇3-激酶（PI 3 K）/Akt/哺乳动物雷帕霉素靶蛋白（mTOR）信号通路促进HNC进展。在小鼠HNC模型中，我们发现BMMSC促进肿瘤的生长、侵袭、转移，并增强肿瘤组织中POX 4和EMT的表达。临床标本分析进一步证实，POX 4和N-cadherin的表达与HNC的病理分级和淋巴结转移有关。综上所述，本研究表明BMMSC通过POSTs介导的PI 3 K/Akt/mTOR激活促进头颈癌的增殖、侵袭、存活、致瘤性和迁移。
Bone marrow mesenchymal stem cells (BMMSC) have been shown to be recruited to the tumor microenvironment and exert a tumor‐promoting effect in a variety of cancers. However, the molecular mechanisms related to the tumor‐promoting effect of BMMSC on head and neck cancer (HNC) are not clear. In this study, we investigated Periostin (POSTN) and its roles in the tumor‐promoting effect of BMMSC on HNC. In vitro analysis of HNC cells cultured in BMMSC‐conditioned media (MSC‐CM) showed that MSC‐CM significantly promoted cancer progression by enhancing cell proliferation, migration, epithelial‐mesenchymal transformation (EMT), and altering expression of cell cycle regulatory proteins and inhibition of apoptosis. Moreover, MSC‐CM promoted the expression of POSTN and POSTN promoted HNC progression through the activation of the phosphoinositide 3‐kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway. In a murine model of HNC, we found that BMMSC promoted tumor growth, invasion, metastasis and enhanced the expression of POSTN and EMT in tumor tissues. Clinical sample analysis further confirmed that the expression of POSTN and N‐cadherin were correlated with pathological grade and lymph node metastasis of HNC. In conclusion, this study indicated that BMMSC promoted proliferation, invasion, survival, tumorigenicity and migration of head and neck cancer through POSTN‐mediated PI3K/Akt/mTOR activation.
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骨膜素经常过表达，并增强口腔癌的侵袭和血管生成。
影响因子：
8.8
作者：
通讯作者：
--
间充质干细胞通过下调全身性抗肿瘤免疫反应来促进肺癌细胞的转移。
影响因子：
4.3
作者：
Gazdic M;Simovic Markovic B;Jovicic N;Misirkic-Marjanovic M;Djonov V;Jakovljevic V;Arsenijevic N;Lukic ML;Volarevic V
通讯作者：
Volarevic V
影响因子：
3.4
作者：
Han, Myung Woul;Lee, Jong Cheol;Kim, Sang Yoon
通讯作者：
Kim, Sang Yoon
影响因子：
6
作者：
Rappa, Germana;Mercapide, Javier;Lorico, Aurelio
通讯作者：
Lorico, Aurelio
人骨髓间充质干细胞诱导胶原蛋白产生和舌癌侵袭。
影响因子：
3.7
作者：
Salo S;Bitu C;Merkku K;Nyberg P;Bello IO;Vuoristo J;Sutinen M;Vähänikkilä H;Costea DE;Kauppila JH;Lehenkari P;Dayan D;Vered M;Risteli J;Salo T
通讯作者：
Salo T