White matter correlates of sensory processing in autism spectrum disorders.
White matter correlates of sensory processing in autism spectrum disorders.
复制标题
DOI：
10.1016/j.nicl.2014.09.018
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Cascio CJ
中科院分区：
文献类型：
--
作者：
Pryweller JR;Schauder KB;Anderson AW;Heacock JL;Foss-Feig JH;Newsom CR;Loring WA;Cascio CJ
自闭症谱系障碍（Autism spectrum disorder， ASD）以非典型社会交际行为、感觉运动障碍和神经发育轨迹异常为特征。DTI已被用于确定白质完整性异常的存在和性质，这可能有助于表征ASD的行为现象。尽管在行为学文献中，ASD的非典型感觉反应模式得到了很好的记录，但对与异常感觉处理相关的神经网络知之甚少。为了研究基础感觉、感觉关联和早期注意过程在ASD感觉反应中的作用，我们的研究集中在已知参与这些不同阶段感觉加工的五个白质纤维束：上放射状冠、半瓣膜中心、下纵向束、内囊后肢和脾。我们获得了32名ASD儿童和26名5至8岁的正常发育儿童的高角分辨率扩散图像。我们还进行了感官评估，以检查白质完整性和感官变量之间的脑行为关系。我们的研究结果表明，下纵束和脾在ASD的非典型感觉运动和早期注意过程中起调节作用。触觉防御能力的增强与下纵束各向异性的减少有关，这可能反映了颞叶边缘结构与下顶叶皮层之间的异常连接。我们的研究结果也证实了脾在注意定向中的调节作用，但表明ASD中社会定向可能存在更分散或可分离的网络。未来的研究应考虑使用全脑分析对白质微观结构进行更可靠的评估。首次将观察到的感觉行为与白质完整性联系起来的ASD研究表明，异常的边缘连接与触觉防御有关。结果证实了脾在定位中的调节作用。研究结果表明，自闭症谱系障碍患者的社会定向存在一个更分散或可分离的网络。
Autism spectrum disorder (ASD) has been characterized by atypical socio-communicative behavior, sensorimotor impairment and abnormal neurodevelopmental trajectories. DTI has been used to determine the presence and nature of abnormality in white matter integrity that may contribute to the behavioral phenomena that characterize ASD. Although atypical patterns of sensory responding in ASD are well documented in the behavioral literature, much less is known about the neural networks associated with aberrant sensory processing. To address the roles of basic sensory, sensory association and early attentional processes in sensory responsiveness in ASD, our investigation focused on five white matter fiber tracts known to be involved in these various stages of sensory processing: superior corona radiata, centrum semiovale, inferior longitudinal fasciculus, posterior limb of the internal capsule, and splenium. We acquired high angular resolution diffusion images from 32 children with ASD and 26 typically developing children between the ages of 5 and 8. We also administered sensory assessments to examine brain-behavior relationships between white matter integrity and sensory variables. Our findings suggest a modulatory role of the inferior longitudinal fasciculus and splenium in atypical sensorimotor and early attention processes in ASD. Increased tactile defensiveness was found to be related to reduced fractional anisotropy in the inferior longitudinal fasciculus, which may reflect an aberrant connection between limbic structures in the temporal lobe and the inferior parietal cortex. Our findings also corroborate the modulatory role of the splenium in attentional orienting, but suggest the possibility of a more diffuse or separable network for social orienting in ASD. Future investigation should consider the use of whole brain analyses for a more robust assessment of white matter microstructure. First study of ASD to link observed sensory behaviors to white matter integrity Findings suggest that aberrant limbic connectivity is related to tactile defensiveness. Findings corroborate modulatory role of splenium in orienting. Findings suggest a more diffuse or separable network for social orienting in ASD.
登录
查看更多内容
影响因子：
5.7
作者：
Alexander, Andrew L.;Lee, Jee Eun;Lainhart, Janet E.
通讯作者：
Lainhart, Janet E.
影响因子：
5.7
作者：
Cheng, Yawei;Chou, Kun-Hsien;Lin, Ching-Po
通讯作者：
Lin, Ching-Po
DOI：
10.1016/j.jmr.2011.09.022
发表时间：
1996-06-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
Basser, PJ;Pierpaoli, C
通讯作者：
Pierpaoli, C
影响因子：
2
作者：
Callejas, A;Lupiàñez, J;Tudela, P
通讯作者：
Tudela, P
影响因子：
3.9
作者：
Brock, M. E.;Freuler, A.;Baranek, G. T.;Watson, L. R.;Poe, M. D.;Sabatino, A.
通讯作者：
Sabatino, A.