Gemfibrozil attenuates the inflammatory response and protects rats from abdominal sepsis.
Gemfibrozil attenuates the inflammatory response and protects rats from abdominal sepsis.
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DOI：
10.3892/etm.2015.2190
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发表时间：
2015-03
影响因子：
2.7
通讯作者：
Fernandez-Garza NE
中科院分区：
文献类型：
--
作者：
Cámara-Lemarroy CR;Guzman-DE LA Garza FJ;Cordero-Perez P;Ibarra-Hernandez JM;Muñoz-Espinosa LE;Fernandez-Garza NE
脓毒症是一种严重疾病，其特征是感染过程会诱发严重的全身炎症反应。在这项研究中，使用盲肠结扎穿刺（CLP）大鼠模型研究了吉非贝齐（GFZ）对腹部脓毒症相关炎症反应的影响。将雄性Wistar大鼠随机分为三组：假手术组（sham），进行剖腹手术，操作肠道，结扎盲肠但不刺穿；对照组，进行CLP； GFZ 组在接受 CLP 之前接受了 GFZ。然后将各组细分为三个不同的时间点：2、4 和 24 小时，表示获取血液样本进行分析的时间。测定肿瘤坏死因子-α（TNF-α）、白细胞介素-1（IL-1）、丙二醛（MDA）、天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）和乳酸脱氢酶（LDH）的血清浓度。与假手术组相比，CLP 后 LDH、AST 和 ALT 值显着升高，而 GFZ 治疗能够降低这些升高。 GFZ 还降低了脓毒症引起的 TNF-α 和 IL-1 升高。总之，GFZ 治疗能够通过减少炎症细胞因子的释放来减弱与 CLP 诱导的脓毒症相关的炎症反应，从而减少组织损伤和氧化应激。
Sepsis is a serious condition characterized by an infectious process that induces a severe systemic inflammatory response. In this study, the effects of gemfibrozil (GFZ) on the inflammatory response associated with abdominal sepsis were investigated using a rat model of cecal-ligation and puncture (CLP). Male Wistar rats were randomly divided into three groups: Sham-operated group (sham), where laparotomy was performed, the intestines were manipulated, and the cecum was ligated but not punctured; control group, subjected to CLP; and GFZ group, which received GFZ prior to undergoing CLP. The groups were then subdivided into three different time-points: 2, 4 and 24 h, indicating the time at which blood samples were obtained for analysis. Serum concentrations of tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), malondialdehyde (MDA), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) were determined. The LDH, AST and ALT values were significantly elevated following CLP compared with those in the sham group, and GFZ treatment was able to reduce these elevations. GFZ also reduced the sepsis-induced elevations of TNF-α and IL-1. In conclusion, GFZ treatment was able to attenuate the inflammatory response associated with CLP-induced sepsis, by diminishing the release of inflammatory cytokines, thereby reducing tissue injury and oxidative stress.
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影响因子：
158.5
作者：
Ranieri, V. Marco;Thompson, B. Taylor;Williams, Mark D.
通讯作者：
Williams, Mark D.
DOI：
10.1097/shk.0b013e31823f1a00
发表时间：
2012-02
期刊：
Shock (Augusta, Ga.)
影响因子：
--
作者：
Standage SW;Caldwell CC;Zingarelli B;Wong HR
通讯作者：
Wong HR
影响因子：
2.2
作者：
Koksal, GM;Sayilgan, C;Uzun, H
通讯作者：
Uzun, H
影响因子：
3.6
作者：
Maitra U;Chang S;Singh N;Li L
通讯作者：
Li L
影响因子：
--
作者：
Olukman M;Sezer ED;Ulker S;Sözmen EY;Cınar GM
通讯作者：
Cınar GM