A multi-stakeholder perspective on the use of alternative test strategies for nanomaterial safety assessment.
A multi-stakeholder perspective on the use of alternative test strategies for nanomaterial safety assessment.
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DOI：
10.1021/nn4037927
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发表时间：
2013-08-27
期刊：
影响因子：
17.1
通讯作者：
Wong, Jeffrey
中科院分区：
文献类型：
--
作者：
Nel, Andre E.;Nasser, Elina;Godwin, Hilary;Avery, David;Bahadori, Tina;Bergeson, Lynn;Beryt, Elizabeth;Bonner, James C.;Boverhof, Darrell;Carter, Janet;Castranova, Vince;DeShazo, J. R.;Hussain, Saber M.;Kane, Agnes B.;Klaessig, Frederick;Kuempel, Eileen;Lafranconi, Mark;Landsiedel, Robert;Malloy, Timothy;Miller, Mary Beth;Morris, Jeffery;Moss, Kenneth;Oberdorster, Gunter;Pinkerton, Kent;Pleus, Richard C.;Shatkin, Jo Anne;Thomas, Russell;Tolaymat, Thabet;Wang, Amy;Wong, Jeffrey
毒理学研究的概念发生了转变，从描述发生了什么，到解释不利结果是如何发生的，从而使人们能够更深入和更好地理解生物分子和机制特征分析如何为危险识别和改进风险评估提供信息。与严重依赖动物的传统毒理学方法相比，产生毒理学数据的新方法正在变得可用于化学品的安全评估，包括高通量和高含量筛选(HTS、HCS)。随着纳米技术的出现，用于研究、开发和商业化的工程纳米材料(ENM)的总数呈指数级增长，需要一种强有力的科学方法来快速有效地筛选ENM对人类和环境的安全性。在化学测试发展的推动下，ENMS的一种新的毒理学范式是使用替代测试策略(ATS)，它通过使用体外和计算机方法，如HTS，HCS和计算模拟来减少对动物测试的依赖。此外，这还允许同时对大量环境污染物进行比较分析，并在产品开发过程和整个生命周期的不同阶段进行危险评估。以碳纳米管为例，在加州大学洛杉矶分校召开了一次研讨会，汇聚了来自政府、工业界和学术界的国家和国际领导人，讨论ATS在环氧氯丙烷决策分析中的作用。经过热烈的讨论，形成了关于这一主题的普遍一致的观点的简短清单，其中包括一种普遍的观点，即针对环境卫生物质的ATS方法可以极大地有利于化学安全分析。
There has been a conceptual shift in toxicological studies from describing what happens to explaining how the adverse outcome occurs, thereby enabling a deeper and improved understanding of how biomolecular and mechanistic profiling can inform hazard identification and improve risk assessment. Compared to traditional toxicology methods, which have a heavy reliance on animals, new approaches to generate toxicological data are becoming available for the safety assessment of chemicals, including high-throughput and high-content screening (HTS, HCS). With the emergence of nanotechnology, the exponential increase in the total number of engineered nanomaterials (ENMs) in research, development, and commercialization requires a robust scientific approach to screen ENM safety in humans and the environment rapidly and efficiently. Spurred by the developments in chemical testing, a promising new toxicological paradigm for ENMs is to use alternative test strategies (ATS), which reduce reliance on animal testing through the use of in vitro and in silico methods such as HTS, HCS, and computational modeling. Furthermore, this allows for the comparative analysis of large numbers of ENMs simultaneously and for hazard assessment at various stages of the product development process and overall life cycle. Using carbon nanotubes as a case study, a workshop bringing together national and international leaders from government, industry, and academia was convened at the University of California, Los Angeles to discuss the utility of ATS for decision-making analyses of ENMs. After lively discussions, a short list of generally shared viewpoints on this topic was generated, including a general view that ATS approaches for ENMs can significantly benefit chemical safety analysis.
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影响因子：
10
作者：
Hinderliter PM;Minard KR;Orr G;Chrisler WB;Thrall BD;Pounds JG;Teeguarden JG
通讯作者：
Teeguarden JG
影响因子：
10.4
作者：
Bonner JC;Silva RM;Taylor AJ;Brown JM;Hilderbrand SC;Castranova V;Porter D;Elder A;Oberdörster G;Harkema JR;Bramble LA;Kavanagh TJ;Botta D;Nel A;Pinkerton KE
通讯作者：
Pinkerton KE
影响因子：
10
作者：
Hamilton RF;Wu N;Porter D;Buford M;Wolfarth M;Holian A
通讯作者：
Holian A
影响因子：
2.5
作者：
Kuempel, E. D.;Castranova, V.;Schulte, P. A.
通讯作者：
Schulte, P. A.
影响因子：
10.4
作者：
Cote I;Anastas PT;Birnbaum LS;Clark RM;Dix DJ;Edwards SW;Preuss PW
通讯作者：
Preuss PW