Differential distribution of the tetrodotoxin‐sensitive rPN4/NaCh6/Scn8a sodium channel in the nervous system
Differential distribution of the tetrodotoxin‐sensitive rPN4/NaCh6/Scn8a sodium channel in the nervous system
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河豚毒素敏感的rPN4/NaCh6/Scn8a钠通道在神经系统中的差异分布
DOI：
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发表时间：
2000
影响因子：
4.2
通讯作者：
S. Novaković
中科院分区：
文献类型：
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作者：
E. Tzoumaka;Angela C. Tischler;L. Sangameswaran;R. Eglen;J. Hunter;S. Novaković
电压门控钠通道是可兴奋细胞产生动作电位的基础。不同的钠通道亚型已被克隆、功能表达，并根据其生物物理性质或对河豚毒素(TTX)的不同敏感性进行区分。在本研究中，我们研究了TTX敏感的钠通道rPN4/NaCH6/Scn8a在大鼠神经系统离散区域的免疫定位。因此，在幼稚动物中，PN4在脑、脊髓、背根神经节(DRG)和周围神经中大量表达。PN4存在于坐骨神经的Ranvier结，提示这一钠通道在周围神经传导中的重要性。此外，还观察了慢性压迫性神经损伤(CCI)大鼠背根神经节、脊髓和坐骨神经中PN4的免疫标记模式。J.神经学Res.60：37-44,2000-2000 Wiley-Liss，Inc.
Voltage‐gated sodium channels underlie the generation of action potentials in excitable cells. Various sodium channel isoforms have been cloned, functionally expressed and distinguished on the basis of their biophysical properties or differential sensitivity to tetrodotoxin (TTX). In the present study, we have investigated the immunolocalization of the TTX‐sensitive sodium channel, rPN4/NaCh6/Scn8a, in discrete areas of the rat nervous system. Thus, in naïve animals, PN4 was abundantly expressed in brain, spinal cord, dorsal root ganglia (DRG) and peripheral nerve. The presence of PN4 at the nodes of Ranvier in the sciatic nerve suggests the importance of this sodium channel in peripheral nerve conduction. In addition, the pattern of PN4 immunolabeling was determined in DRG, spinal cord and sciatic nerve in rats subjected to chronic constriction nerve injury (CCI). J. Neurosci. Res. 60:37–44, 2000 © 2000 Wiley‐Liss, Inc.
影响因子：
2.5
作者：
RIZZO, MA;KOCSIS, JD;WAXMAN, SG
通讯作者：
WAXMAN, SG
DOI：
10.1073/pnas.94.4.1527
发表时间：
1997-02-18
影响因子：
11.1
作者：
ToledoAral, JJ;Moss, BL;Mandel, G
通讯作者：
Mandel, G
影响因子：
2.5
作者：
XIE, YK;ZHANG, JM;LAMOTTE, RH
通讯作者：
LAMOTTE, RH