Polo-like kinase 1 overexpression is an early event in the progression of papillary carcinoma.
Polo-like kinase 1 overexpression is an early event in the progression of papillary carcinoma.
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DOI：
10.1038/sj.bjc.6601540
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发表时间：
2004-01-26
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
Polo样激酶1（PLK 1）是一种丝氨酸/苏氨酸激酶，参与细胞有丝分裂，被认为是细胞增殖的标志。然而，其在人类肿瘤中的蛋白表达尚未得到深入研究。我们研究了PLK 1在各种甲状腺肿瘤中的表达，以阐明其在甲状腺癌中的生理意义。正常滤泡细胞仅偶见PLK 1表达。在滤泡性肿瘤和间变性癌中，PLK 1过表达并不常见，仅5.9%的滤泡性腺瘤、7.1%的滤泡性癌和11.8%的间变性癌过表达该蛋白。然而，43.7%的乳头状癌过表达PLK 1。Polo样激酶1在较小的乳头状癌病变中更常见，62.5%的微小癌（范围从4 mm到1.0 cm）甚至66.7%的偶发癌（小于4 mm）过表达，而这种现象仅见于20.0%的大于4.0 cm的病变。此外，PLK 1过表达与Ki-67标记指数评估的细胞增殖活性无关，但与UICC分期、甲状腺外浸润和Sakamoto等人提出的低分化病变的存在呈负相关。这些发现强烈表明，与先前研究的其他癌症不同，PLK 1不作为细胞周期调节剂，但在乳头状癌中起组成性作用，特别是在早期阶段，并可能有助于这种癌的恶性转化。
Polo-like kinase 1 (PLK1) is one of the serine threonine kinases that contributes to cell mitosis and is regarded as a marker of cellular proliferation. However, its protein expression in human carcinoma has not been studied in depth. We investigated PLK1 expression in various thyroid neoplasms in order to elucidate its physiological significance in thyroid carcinoma. Normal follicular cells only occasionally expressed PLK1. In follicular tumours and anaplastic carcinoma, PLK1 overexpression was not a common event and only 5.9% of follicular adenoma, 7.1% of follicular carcinoma, and 11.8% of anaplastic carcinoma overexpressed this protein. However, 43.7% of papillary carcinoma overexpressed PLK1. Polo-like kinase 1 overexpression was more frequently observed in smaller papillary carcinoma lesions, and 62.5% of microcarcinoma (ranging from 4 mm to 1.0 cm) and even 66.7% of incidental carcinoma (less than 4 mm) overexpressed it, whereas this phenomenon could only be seen in 20.0% of lesions larger than 4.0 cm. Furthermore, PLK1 overexpression was not related to cell-proliferating activity evaluated by Ki-67 labelling index, but it was inversely linked to UICC stage, extrathyroidal invasion, and the presence of poorly differentiated lesion as proposed by Sakamoto et al. These findings strongly suggest that, unlike other carcinomas previously studied, PLK1 does not act as a cell cycle regulator but plays a constitutive role in papillary carcinoma especially in the early phase, and may contribute to the malignant transformation of this carcinoma.
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DOI：
10.1083/jcb.129.6.1617
发表时间：
1995-06
期刊：
The Journal of cell biology
影响因子：
--
作者：
Golsteyn RM;Mundt KE;Fry AM;Nigg EA
通讯作者：
Nigg EA
影响因子：
8
作者：
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影响因子：
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DOI：
10.1073/pnas.91.5.1736
发表时间：
1994-03-01
影响因子：
11.1
作者：
HOLTRICH, U;WOLF, G;STREBHARDT, K
通讯作者：
STREBHARDT, K
影响因子：
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