Synchronization and desynchronization in epilepsy: controversies and hypotheses.
Synchronization and desynchronization in epilepsy: controversies and hypotheses.
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DOI：
10.1113/jphysiol.2012.239590
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发表时间：
2013-02-15
期刊：
影响因子：
--
通讯作者：
Schindler K
中科院分区：
文献类型：
--
作者：
Jiruska P;de Curtis M;Jefferys JG;Schevon CA;Schiff SJ;Schindler K
癫痫历来被视为一种功能性脑部疾病，与大量神经元群过度同步导致超同步状态有关。最近的证据表明，癫痫样现象，特别是癫痫发作，是由神经元网络之间复杂的相互作用引起的，其特征是神经元放电的异质性和同步的动态演化。 Desynchronization is often observed preceding seizures or during their early stages; in contrast, high levels of synchronization observed towards the end of seizures may facilitate termination. In this review we discuss cellular and network mechanisms responsible for such complex changes in synchronization.最近的工作已经确定了细胞类型特异性的抑制性和兴奋性相互作用、神经元放电和远离该放电的局部场电位的非局部测量之间的二分法，以及在癫痫发作中活跃的非放电神经元中神经元暗物质问题的反映。这些最新进展挑战了长期以来的观点，并导致人们对癫痫的病理生理学有了更严格和现实的理解。
Epilepsy has been historically seen as a functional brain disorder associated with excessive synchronization of large neuronal populations leading to a hypersynchronous state. Recent evidence showed that epileptiform phenomena, particularly seizures, result from complex interactions between neuronal networks characterized by heterogeneity of neuronal firing and dynamical evolution of synchronization. Desynchronization is often observed preceding seizures or during their early stages; in contrast, high levels of synchronization observed towards the end of seizures may facilitate termination. In this review we discuss cellular and network mechanisms responsible for such complex changes in synchronization. Recent work has identified cell-type-specific inhibitory and excitatory interactions, the dichotomy between neuronal firing and the non-local measurement of local field potentials distant to that firing, and the reflection of the neuronal dark matter problem in non-firing neurons active in seizures. These recent advances have challenged long-established views and are leading to a more rigorous and realistic understanding of the pathophysiology of epilepsy.
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DOI：
10.1523/jneurosci.5309-08.2009
发表时间：
2009-03-18
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bragin A;Azizyan A;Almajano J;Engel J Jr
通讯作者：
Engel J Jr
影响因子：
5.6
作者：
Bragin, A;Wilson, CL;Engel, T
通讯作者：
Engel, T
影响因子：
64.8
作者：
JEFFERYS, JGR;HAAS, HL
通讯作者：
HAAS, HL
影响因子：
8.6
作者：
Brown, R;Rulkov, NF
通讯作者：
Rulkov, NF
影响因子：
3.4
作者：
de Curtis, M;Librizzi, L;Biella, G
通讯作者：
Biella, G