Magnetic resonance temperature imaging validation of a bioheat transfer model for laser-induced thermal therapy.
Magnetic resonance temperature imaging validation of a bioheat transfer model for laser-induced thermal therapy.
复制标题
DOI：
10.3109/02656736.2011.557028
复制
发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Stafford RJ
中科院分区：
文献类型：
--
作者：
Fuentes D;Walker C;Elliott A;Shetty A;Hazle JD;Stafford RJ
磁共振引导激光诱导热疗（MRgLITT）目前正在进行治疗人类颅内病变的初步安全性和可行性临床研究。随着研究朝着治疗效果评估的方向发展，预测计算模型可能在前瞻性3D治疗计划中发挥重要作用。当前的工作在脑部MRgLITT手术的犬模型中，针对回顾性多平面MR热成像（MRTI）严格评估了激光诱导生物热传递的计算模型。使用将Pennes方程耦合到组织中光传输的扩散理论近似的生物热传递的3D有限元模型。激光源与施用器几何形状共形建模。Dirichlet边界条件用于模拟主动冷却导管的温度。使用1 cm漫射尖端15 W二极管激光器（980 nm）对n = 4只犬进行MRgLITT手术。加权L2范数被用作时空MR导出的温度估计和模型预测之间的比较的度量。计算模型和MRTI之间的归一化误差历史在MRTI噪声的1-4个标准差内。主动冷却模型表明，施用器温度对达到的最高温度有很大影响，但不会显著降低远离活动头端的组织温度。结果表明，生物热传递的计算模型可以提供一个合理的近似的激光-组织相互作用，这可能是有用的治疗计划，但不能轻易取代MR温度成像在一个复杂的环境，如大脑。
Magnetic resonance-guided laser-induced thermal therapy (MRgLITT) is currently undergoing initial safety and feasibility clinical studies for the treatment of intracranial lesions in humans. As studies progress towards evaluation of treatment efficacy, predictive computational models may play an important role for prospective 3D treatment planning. The current work critically evaluates a computational model of laser induced bioheat transfer against retrospective multiplanar MR thermal imaging (MRTI) in a canine model of the MRgLITT procedure in the brain. A 3D finite element model of the bioheat transfer that couples Pennes equation to a diffusion theory approximation of light transport in tissue is used. The laser source is modelled conformal with the applicator geometry. Dirichlet boundary conditions are used to model the temperature of the actively cooled catheter. The MRgLITT procedure was performed on n = 4 canines using a 1-cm diffusing tip 15-W diode laser (980 nm). A weighted L2 norm is used as the metric of comparison between the spatiotemporal MR-derived temperature estimates and model prediction. The normalised error history between the computational models and MRTI was within 1–4 standard deviations of MRTI noise. Active cooling models indicate that the applicator temperature has a strong effect on the maximum temperature reached, but does not significantly decrease the tissue temperature away from the active tip. Results demonstrate the computational model of the bioheat transfer may provide a reasonable approximation of the laser–tissue interaction, which could be useful for treatment planning, but cannot readily replace MR temperature imaging in a complex environment such as the brain.
登录
查看更多内容
影响因子：
5
作者：
Erguvan-Dogan, Basak;Whitman, Gary J.;Middleton, Lavinia P.
通讯作者：
Middleton, Lavinia P.
影响因子：
3.3
作者：
DETRE, JA;LEIGH, JS;KORETSKY, AP
通讯作者：
KORETSKY, AP
影响因子：
3.3
作者：
Bankson, JA;Wright, SM
通讯作者：
Wright, SM
DOI：
10.1115/1.4001395
发表时间：
2010-06-01
影响因子：
1.7
作者：
Chen, Xin;Saidel, Gerald M.
通讯作者：
Saidel, Gerald M.
影响因子：
3.3
作者：
Bankson, JA;Stafford, RJ;Hazle, JD
通讯作者：
Hazle, JD