Gender-dependent correlations of carotid intima-media thickness with gene expression in blood.
Gender-dependent correlations of carotid intima-media thickness with gene expression in blood.
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DOI：
10.1007/s12975-011-0066-4
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发表时间：
2011-06
影响因子：
6.9
通讯作者：
Sharp FR
中科院分区：
文献类型：
--
作者：
Turner RJ;Bushnell CD;Register TC;Sharp FR
中风发病率、风险和结局的性别差异的机制尚不确定。我们试图确定男性和女性循环血细胞的转录谱是否与颈动脉内膜中层厚度（CIMT）（动脉粥样硬化和中风风险的预测因子）有差异相关。使用Affyphin表达阵列测量了年龄在45-64岁之间的男性（n=17）和女性（n=35）的全血中的基因表达，其中至少有一个中风的风险因素。采用B超测量平均CIMT。仅在女性中与CIMT呈正相关的基因有746个，与CIMT呈负相关的基因有292个（p<0.05），仅在男性中与CIMT呈正相关的基因有881个，与CIMT呈负相关的基因有597个（p<0.05）。41个基因与男性和女性的CIMT相关，但方向相反。这些基因与雌激素、胆固醇和脂质代谢、炎症、凝血和血管反应性相关。这项初步研究首次证明了血细胞中的基因表达与CIMT相关。这些结果指出潜在的病理生理机制的性别差异中风的风险。由于样本量较小，研究结果是初步的，需要在独立的更大规模的研究中得到证实。
The mechanisms underlying gender differences in stroke incidence, risk, and outcome are uncertain. We sought to determine whether transcriptional profiles of circulating blood cells of men and women differentially correlated with carotid artery intima–media thickness (CIMT), a predictor of atherosclerosis and stroke risk. Gene expression in whole blood was measured using Affymetrix expression arrays in men (n=17) and women (n=35), aged 45–64 years, with at least one risk factor for stroke. Mean average CIMT was measured using B-mode ultrasound. Expression levels of 746 genes positively and 292 genes negatively correlated with CIMT only in women (p<0.05); 881 genes positively and 597 genes negatively correlated with CIMT only in men (p<0.05). Forty-one genes correlated with CIMT in men and women, but in opposite directions. These genes were associated with estrogen, cholesterol and lipid metabolism, inflammation, coagulation, and vasoreactivity. This pilot study provides the first proof of principle that gene expression in blood cells correlates with CIMT. These results point to potential pathophysiological mechanisms underlying sex differences in stroke risk. Since the sample size is small, the findings are preliminary and need to be confirmed in independent, larger studies.
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