Blood markers of alcoholic liver disease.

Blood markers of alcoholic liver disease.
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酒精性肝病的血液标志物。

DOI:
10.1007/978-1-4615-7718-8_20
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发表时间:
1988
期刊:
Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism
影响因子:
--
通讯作者:
Lieber,CS
Lieber,CS
中科院分区:
--
文献类型:
--
作者:
Lieber,CS

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并不是所有酗酒者都会患上严重的酒精性肝病。可能涉及遗传因素,但到目前为止还没有开发出相应的有用标记。更具实用性的是对肝脏早期变化的认识,这些变化可能表明瘢痕形成或纤维化的过程已经开始。纤维组织的蛋白质--胶原蛋白的分解产物的测定已被发现有助于检测这些早期阶段。对血清中谷氨酸脱氢酶活性的评估也提供了一些肝脏炎症和坏死程度的指标,但不能反映酒精摄入量。后者的严重程度可以用各种生物标志物来评估,最近添加了针对乙醛加合物的循环抗体。
Not all heavy drinkers develop severe alcoholic liver disease. Genetic factors are probably involved, but no corresponding useful markers have been developed thus far. Of greater practical applicability is the recognition of early changes in the liver that may indicate that the process of scarring or fibrosis has been initiated. Measurement of breakdown products of collagen, the protein of the fibrotic tissue, have been found to be useful for detecting these early stages. Assessment of glutamic dehydrogenase activity in the serum also provides some indication of the degree of inflammation and necrosis present in the liver, but not of the alcohol intake. The severity of the latter can be assessed with a variety of biological markers, to which circulating antibodies against acetaldehyde adducts have recently been added.
HLA 和酒精性肝硬化。
DOI: 10.1111/j.1399-0039.1982.tb01410.x
发表时间: 1982
期刊: Tissue antigens
影响因子: --
作者:
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通讯作者: I. Mackay
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影响因子: 29.4
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影响因子: --
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发表时间: 1978
影响因子: --
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