A sticky end for gastrointestinal helminths; the role of the mucus barrier.
A sticky end for gastrointestinal helminths; the role of the mucus barrier.
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DOI：
10.1111/pim.12517
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发表时间：
2018-04
影响因子：
2.2
通讯作者：
Grencis RK
中科院分区：
文献类型：
--
作者：
Sharpe C;Thornton DJ;Grencis RK
胃肠道线虫是一组成功的多细胞寄生虫，它们已经进化到在多个物种的肠道生态位内共存。据估计，超过10%的世界人口被胃肠道线虫慢性感染，使这组寄生线虫成为全球健康的主要负担。尽管受影响的个体数量很大，但几乎没有有效的治疗方法来根除这些感染。对胃肠道线虫感染的研究主要集中在确定对宿主保护的免疫学和病理学后果。保护宿主的一个重要但被忽视的方面是粘液，粘液只是一个简单的屏障的概念不再成立。事实上，粘液是一种高度调节和动态分泌的基质，由高度糖基化的粘蛋白的物理水合网络支撑，越来越多的人认为它对胃肠道线虫感染具有关键的保护作用。在感染过程中，解开粘蛋白、底层上皮和免疫细胞之间复杂的相互作用是一个重大挑战，并且需要完全确定粘液屏障的保护作用。本文综述了胃肠道线虫感染过程中粘蛋白和粘液屏障的知识现状，特别关注小鼠感染模型。
Gastrointestinal (GI) nematodes are a group of successful multicellular parasites that have evolved to coexist within the intestinal niche of multiple species. It is estimated that over 10% of the world's population are chronically infected by GI nematodes, making this group of parasitic nematodes a major burden to global health. Despite the large number of affected individuals, there are few effective treatments to eradicate these infections. Research into GI nematode infections has primarily focused on defining the immunological and pathological consequences on host protection. One important but neglected aspect of host protection is mucus, and the concept that mucus is just a simple barrier is no longer tenable. In fact, mucus is a highly regulated and dynamic‐secreted matrix, underpinned by a physical hydrated network of highly glycosylated mucins, which is increasingly recognized to have a key protective role against GI nematode infections. Unravelling the complex interplay between mucins, the underlying epithelium and immune cells during infection are a major challenge and are required to fully define the protective role of the mucus barrier. This review summarizes the current state of knowledge on mucins and the mucus barrier during GI nematode infections, with particular focus on murine models of infection.
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影响因子：
4.4
作者：
Albert, Timo K.;Laubinger, Werner;Hoffmann, Werner
通讯作者：
Hoffmann, Werner
影响因子：
1.3
作者：
Basso, W;Venturini, L;Dubey, JP
通讯作者：
Dubey, JP
影响因子：
64.8
作者：
Gerbe F;Sidot E;Smyth DJ;Ohmoto M;Matsumoto I;Dardalhon V;Cesses P;Garnier L;Pouzolles M;Brulin B;Bruschi M;Harcus Y;Zimmermann VS;Taylor N;Maizels RM;Jay P
通讯作者：
Jay P
影响因子：
4.1
作者：
CARLSTEDT, I;LINDGREN, H;WINGERUP, L
通讯作者：
WINGERUP, L
DOI：
10.1152/ajpgi.2001.280.5.g922
发表时间：
2001-05-01
影响因子：
4.5
作者：
Atuma, C;Strugala, V;Holm, L
通讯作者：
Holm, L