Synaptic Homeostasis and Allostasis in the Dentate Gyrus Caused by Inflammatory and Neuropathic Pain Conditions.
Synaptic Homeostasis and Allostasis in the Dentate Gyrus Caused by Inflammatory and Neuropathic Pain Conditions.
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炎症和神经性疼痛引起的齿状回突触稳态和失衡。
DOI：
10.3389/fnsyn.2018.00001
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发表时间：
2018
影响因子：
3.7
通讯作者：
Chen J
中科院分区：
文献类型：
--
作者：
Wang RR;Wang Y;Guan SM;Li Z;Kokane S;Cao FL;Sun W;Li CL;He T;Yang Y;Lin Q;Chen J
人们普遍认为，疼痛可以在突触水平上造成兴奋和抑制(内稳态)之间的失衡。然而，在不同的疼痛条件下，中枢神经系统的这种不平衡(同素平衡)是如何发展的，目前还知之甚少。在这里，我们分析了在两种不同病因和持续时间的疼痛条件下，齿状回兴奋性和抑制性突触传递和调制的变化。首先，与对照组相比，在急性炎症性和慢性神经病理性疼痛条件下，刺激穿通通路(PP)后诱发的兴奋性突触后电流(EEPSCs)的输入-输出(I/O)曲线的函数被获得。然而，PP诱发的抑制性突触后电流(EIPSCs)的I/O曲线在两种情况下的作用不同，即炎症条件下可获得较大幅度的突触后电流，而神经病变条件下则相反。在炎症状态下，微型IPSCs的频率和幅度均增加，而在神经病理性状态下，其频率和幅度均降低。神经病理性疼痛状态下DG颗粒细胞对电流刺激的放电明显增加，而炎症性疼痛状态下DG颗粒细胞放电与对照组无明显差异。这些结果提供了另一条证据，表明在不同的病理性疼痛条件下，抑制控制对兴奋性突触传递的稳态和变态调节，从而暗示在治疗不同的病理性疼痛时，使用不同的治疗方法来维持兴奋和抑制之间的动态平衡。
It has been generally accepted that pain can cause imbalance between excitation and inhibition (homeostasis) at the synaptic level. However, it remains poorly understood how this imbalance (allostasis) develops in the CNS under different pain conditions. Here, we analyzed the changes in both excitatory and inhibitory synaptic transmission and modulation of the dentate gyrus (DG) under two pain conditions with different etiology and duration. First, it was revealed that the functions of the input-output (I/O) curves for evoked excitatory postsynaptic currents (eEPSCs) following the perforant path (PP) stimulation were gained under both acute inflammatory and chronic neuropathic pain conditions relative to the controls. However, the functions of I/O curves for the PP-evoked inhibitory postsynaptic currents (eIPSCs) differed between the two conditions, namely it was greatly gained under inflammatory condition, but was reduced under neuropathic condition in reverse. Second, both the frequency and amplitude of miniature IPSCs (mIPSCs) were increased under inflammatory condition, however a decrease in frequency of mIPSCs was observed under neuropathic condition. Finally, the spike discharge of the DG granule cells in response to current injection was significantly increased by neuropathic pain condition, however, no different change was found between inflammatory pain condition and the control. These results provide another line of evidence showing homeostatic and allostatic modulation of excitatory synaptic transmission by inhibitory controls under different pathological pain conditions, hence implicating use of different therapeutic approaches to maintain the homeostasis between excitation and inhibition while treating different conditions of pathological pain.
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DOI：
10.1523/jneurosci.5387-10.2011
发表时间：
2011-01-19
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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影响因子：
2.5
作者：
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通讯作者：
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