Sequence analysis in Bos taurus reveals pervasiveness of X-Y arms races in mammalian lineages.
Sequence analysis in Bos taurus reveals pervasiveness of X-Y arms races in mammalian lineages.
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DOI：
10.1101/gr.269902.120
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发表时间：
2020-12
期刊：
影响因子：
7
通讯作者：
Page DC
中科院分区：
文献类型：
--
作者：
Hughes JF;Skaletsky H;Pyntikova T;Koutseva N;Raudsepp T;Brown LG;Bellott DW;Cho TJ;Dugan-Rocha S;Khan Z;Kremitzki C;Fronick C;Graves-Lindsay TA;Fulton L;Warren WC;Wilson RK;Owens E;Womack JE;Murphy WJ;Muzny DM;Worley KC;Chowdhary BP;Gibbs RA;Page DC
对Y染色体进化的研究主要集中在基因衰变上，这是抑制与X染色体交叉的结果。在这里，我们提供的证据表明，抑制X-Y交叉释放了第二种动力：自私的X-Y军备竞赛，重塑了哺乳动物的性染色体，就像牛、老鼠和男人一样。利用超分辨率测序，我们探索了公牛的Y染色体，发现它是由大量的、谱系特异性扩增的睾丸表达基因家族主导的，使其成为迄今为止基因密度最高的Y染色体测序。就像在老鼠身上一样，公牛y扩增基因的x连锁同源物已经成为睾丸特异性和扩增的基因。这种进化趋同意味着，通过基因扩增的特定谱系的X-Y共同进化，以及这种现象背后的自私力量，在不同的哺乳动物谱系中占主导地位。与Y基因的衰变一起，X-Y军备竞赛塑造了哺乳动物的性染色体，并影响了哺乳动物的进化过程。
Studies of Y Chromosome evolution have focused primarily on gene decay, a consequence of suppression of crossing-over with the X Chromosome. Here, we provide evidence that suppression of X–Y crossing-over unleashed a second dynamic: selfish X–Y arms races that reshaped the sex chromosomes in mammals as different as cattle, mice, and men. Using super-resolution sequencing, we explore the Y Chromosome of Bos taurus (bull) and find it to be dominated by massive, lineage-specific amplification of testis-expressed gene families, making it the most gene-dense Y Chromosome sequenced to date. As in mice, an X-linked homolog of a bull Y-amplified gene has become testis-specific and amplified. This evolutionary convergence implies that lineage-specific X–Y coevolution through gene amplification, and the selfish forces underlying this phenomenon, were dominatingly powerful among diverse mammalian lineages. Together with Y gene decay, X–Y arms races molded mammalian sex chromosomes and influenced the course of mammalian evolution.
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影响因子：
4.5
作者：
Cocquet J;Ellis PJ;Mahadevaiah SK;Affara NA;Vaiman D;Burgoyne PS
通讯作者：
Burgoyne PS
影响因子：
64.8
作者：
Hughes, Jennifer F.;Skaletsky, Helen;Brown, Laura G.;Pyntikova, Tatyana;Graves, Tina;Fulton, Robert S.;Dugan, Shannon;Ding, Yan;Buhay, Christian J.;Kremitzki, Colin;Wang, Qiaoyan;Shen, Hua;Holder, Michael;Villasana, Donna;Nazareth, Lynne V.;Cree, Andrew;Courtney, Laura;Veizer, Joelle;Kotkiewicz, Holland;Cho, Ting-Jan;Koutseva, Natalia;Rozen, Steve;Muzny, Donna M.;Warren, Wesley C.;Gibbs, Richard A.;Wilson, Richard K.;Page, David C.
通讯作者：
Page, David C.
影响因子：
64.8
作者：
通讯作者：
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影响因子：
9.2
作者：
Chibalina, Margarita V.;Filatov, Dmitry A.
通讯作者：
Filatov, Dmitry A.
影响因子：
30.8
作者：
Daetwyler, Hans D.;Capitan, Aurelien;Hayes, Ben J.
通讯作者：
Hayes, Ben J.