Galectin-9 ameliorates clinical severity of MRL/lpr lupus-prone mice by inducing plasma cell apoptosis independently of Tim-3.
Galectin-9 ameliorates clinical severity of MRL/lpr lupus-prone mice by inducing plasma cell apoptosis independently of Tim-3.
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DOI：
10.1371/journal.pone.0060807
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Hirashima M
中科院分区：
文献类型：
--
作者：
Moritoki M;Kadowaki T;Niki T;Nakano D;Soma G;Mori H;Kobara H;Masaki T;Kohno M;Hirashima M
半乳糖凝集素-9通过调节T细胞和巨噬细胞来改善各种鼠自身免疫性疾病模型，尽管尚不知道它在B细胞中可能具有什么作用。本实验表明，半乳糖凝集素-9改善了多种临床症状，如蛋白尿、关节炎和MRL/lpr狼疮易感小鼠的血细胞比容。如前所述，半乳糖凝集素-9降低了Th 1、Th 17和活化的CD 8 + T细胞的频率。虽然抗dsDNA抗体在MRL/lpr狼疮易感小鼠中增加，但半乳糖凝集素-9至少部分地通过减少浆细胞的数量来抑制抗dsDNA抗体的产生。半乳糖凝集素-9似乎通过诱导浆细胞凋亡而不是通过抑制BAFF产生来减少浆细胞的数量。尽管在MRL/lpr狼疮易感小鼠中约20%的CD 19 −/low CD 138+浆细胞表达Tim-3，但Tim-3可能不直接参与半乳糖凝集素-9诱导的细胞凋亡，因为抗Tim-3阻断抗体不阻断半乳糖凝集素-9诱导的细胞凋亡。这是首次报道半乳糖凝集素-9诱导浆细胞凋亡。总的来说，半乳糖凝集素-9可能通过调节T细胞功能和诱导浆细胞凋亡来减轻MRL狼疮易感小鼠的临床严重程度。
Galectin-9 ameliorates various murine autoimmune disease models by regulating T cells and macrophages, although it is not known what role it may have in B cells. The present experiment shows that galectin-9 ameliorates a variety of clinical symptoms, such as proteinuria, arthritis, and hematocrit in MRL/lpr lupus-prone mice. As previously reported, galectin-9 reduces the frequency of Th1, Th17, and activated CD8+ T cells. Although anti-dsDNA antibody was increased in MRL/lpr lupus-prone mice, galectin-9 suppressed anti-dsDNA antibody production, at least partly, by decreasing the number of plasma cells. Galectin-9 seemed to decrease the number of plasma cells by inducing plasma cell apoptosis, and not by suppressing BAFF production. Although about 20% of CD19−/low CD138+ plasma cells expressed Tim-3 in MRL/lpr lupus-prone mice, Tim-3 may not be directly involved in the galectin-9-induced apoptosis, because anti-Tim-3 blocking antibody did not block galectin-9-induced apoptosis. This is the first report of plasma cell apoptosis being induced by galectin-9. Collectively, it is likely that galectin-9 attenuates the clinical severity of MRL lupus-prone mice by regulating T cell function and inducing plasma cell apoptosis.
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影响因子：
5.1
作者：
Lee, Jaejoon;Park, Eun-Jung;Cha, Hoon-Suk
通讯作者：
Cha, Hoon-Suk
影响因子：
4.9
作者：
Dillon SR;Harder B;Lewis KB;Moore MD;Liu H;Bukowski TR;Hamacher NB;Lantry MM;Maurer M;Krejsa CM;Ellsworth JL;Pederson S;Elkon KB;Wener MH;Dall'Era M;Gross JA
通讯作者：
Gross JA
影响因子：
1.5
作者：
Kleczynska, Weronika;Jakiela, Bogdan;Musial, Jacek
通讯作者：
Musial, Jacek
影响因子：
27.4
作者：
Koyama, T;Tsukamoto, H;Horiuchi, T
通讯作者：
Horiuchi, T
DOI：
10.1084/jem.20081398
发表时间：
2008-11-24
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Jones RB;Ndhlovu LC;Barbour JD;Sheth PM;Jha AR;Long BR;Wong JC;Satkunarajah M;Schweneker M;Chapman JM;Gyenes G;Vali B;Hyrcza MD;Yue FY;Kovacs C;Sassi A;Loutfy M;Halpenny R;Persad D;Spotts G;Hecht FM;Chun TW;McCune JM;Kaul R;Rini JM;Nixon DF;Ostrowski MA
通讯作者：
Ostrowski MA