In silico models of aerosol delivery to the respiratory tract - development and applications.
In silico models of aerosol delivery to the respiratory tract - development and applications.
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DOI：
10.1016/j.addr.2011.05.009
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发表时间：
2012-03-30
影响因子：
16.1
通讯作者：
Holbrook, Landon T.
中科院分区：
文献类型：
--
作者：
Longest, P. Worth;Holbrook, Landon T.
关键词：
这篇综述讨论了应用计算模型来模拟从颗粒或液滴形成到呼吸道内沉积的吸入药物气溶胶的运输和沉积。传统的一维（1-D）的全肺模型进行了简要的讨论，随后更深入的审查三维（3-D）的计算流体动力学（CFD）模拟。CFD模型的审查分为几个部分，包括吸入器装置内的运输和沉积、胸外（口腔和鼻腔）区域、传导气道和肺泡空间。对于每个部分，提供了对模拟药物气溶胶领域的重大贡献和进步的一般性回顾，然后是更深入的应用或案例研究，突出了计算机模型的挑战，实用性和好处。提出的具体应用包括现有喷雾吸入器的优化，电荷靶向递送的开发，最佳鼻腔递送的条件的规范，新的冷凝递送方法的分析，以及使用磁性气溶胶的靶向递送的评价。审查的结论与建议需要更精细的模型验证，使用并发的实验和CFD方法开发气溶胶输送系统，并开发一个随机的个人路径（SIP）模型的气溶胶运输和沉积在整个呼吸道。
This review discusses the application of computational models to simulate the transport and deposition of inhaled pharmaceutical aerosols from the site of particle or droplet formation to deposition within the respiratory tract. Traditional one-dimensional (1-D) whole-lung models are discussed briefly followed by a more in-depth review of three-dimensional (3-D) computational fluid dynamics (CFD) simulations. The review of CFD models is organized into sections covering transport and deposition within the inhaler device, the extrathoracic (oral and nasal) region, conducting airways, and alveolar space. For each section, a general review of significant contributions and advancements in the area of simulating pharmaceutical aerosols is provided followed by a more in-depth application or case study that highlights the challenges, utility, and benefits of in silico models. Specific applications presented include the optimization of an existing spray inhaler, development of charge-targeted delivery, specification of conditions for optimal nasal delivery, analysis of a new condensational delivery approach, and an evaluation of targeted delivery using magnetic aerosols. The review concludes with recommendations on the need for more refined model validations, use of a concurrent experimental and CFD approach for developing aerosol delivery systems, and development of a stochastic individual path (SIP) model of aerosol transport and deposition throughout the respiratory tract.
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影响因子：
4.5
作者：
Balashazy, I;Hofmann, W;Heistracher, T
通讯作者：
Heistracher, T
影响因子：
3.3
作者：
Balásházy, I;Hofmann, W;Heistracher, T
通讯作者：
Heistracher, T
影响因子：
1.8
作者：
Balachandran, W;Machowski, W;Hudson, C
通讯作者：
Hudson, C
DOI：
10.1089/jam.2006.19.473
发表时间：
2006-12-01
期刊：
JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG
影响因子：
--
作者：
Borgstrom, Lars;Olsson, Bo;Thorsson, Lars
通讯作者：
Thorsson, Lars
DOI：
10.1089/08942680152484180
发表时间：
2001-06-01
期刊：
JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG
影响因子：
--
作者：
Cheng, YS;Fu, CS;Zhou, Y
通讯作者：
Zhou, Y