Mast Cells Interact with Endothelial Cells to Accelerate In Vitro Angiogenesis.
Mast Cells Interact with Endothelial Cells to Accelerate In Vitro Angiogenesis.
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DOI：
10.3390/ijms18122674
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发表时间：
2017-12-13
影响因子：
5.6
通讯作者：
Jamur MC
中科院分区：
文献类型：
--
作者：
de Souza Junior DA;Mazucato VM;Santana AC;Oliver C;Jamur MC
血管生成是一个复杂的过程，涉及内皮细胞和各种其他细胞类型以及组织微环境之间的相互作用。先前的一些研究已经证明肥大细胞在血管生成部位聚集。尽管有证据表明肥大细胞和血管生成之间的关系，肥大细胞和内皮细胞的协会仍然知之甚少。本研究旨在探讨肥大细胞和内皮细胞在体外血管生成过程中的相互关系。当内皮细胞与肥大细胞共培养时，血管生成被刺激。此外，有直接的细胞间通讯通过间隙连接之间的两种细胞类型。此外，肥大细胞的存在刺激内皮细胞释放血管生成因子。此外，来自共培养物的条件培养基也刺激体外血管生成。这项研究的结果表明，肥大细胞具有直接和间接的促血管生成作用，并提供了新的见解肥大细胞在血管生成中的作用。
Angiogenesis is a complex process that involves interactions between endothelial cells and various other cell types as well as the tissue microenvironment. Several previous studies have demonstrated that mast cells accumulate at angiogenic sites. In spite of the evidence suggesting a relationship between mast cells and angiogenesis, the association of mast cells and endothelial cells remains poorly understood. The present study aims to investigate the relationship between mast cells and endothelial cells during in vitro angiogenesis. When endothelial cells were co-cultured with mast cells, angiogenesis was stimulated. Furthermore, there was direct intercellular communication via gap junctions between the two cell types. In addition, the presence of mast cells stimulated endothelial cells to release angiogenic factors. Moreover, conditioned medium from the co-cultures also stimulated in vitro angiogenesis. The results from this investigation demonstrate that mast cells have both direct and indirect proangiogenic effects and provide new insights into the role of mast cells in angiogenesis.
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DOI：
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