Adsorbable organic bromine compounds (AOBr) in aquatic samples: a nematode-based toxicogenomic assessment of the exposure hazard
Adsorbable organic bromine compounds (AOBr) in aquatic samples: a nematode-based toxicogenomic assessment of the exposure hazard
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水生样品中的可吸附有机溴化合物（AOBr）：基于线虫的暴露危害毒理学评估
DOI：
10.1007/s11356-015-4694-1
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发表时间：
2015
影响因子：
5.8
通讯作者：
Steinberg CEW
中科院分区：
文献类型：
--
作者：
Saul N;Stürzenbaum SR;Chakrabarti S;Baberschke N;Lieke T;Putschew A;Kochan C;Menzel R;Steinberg CEW
在德国湖泊中检测到可吸附有机溴化合物（AOBr）水平升高，而以合成微囊藻毒素而闻名的微囊藻等蓝藻是天然有机溴的主要生产者之一。然而，很少有人知道有机溴的环境现实浓度如何影响无脊椎动物。在这里，线虫秀丽隐杆线虫暴露于含AOBr的地表水样品和富含铜绿微囊藻的分批培养（MC-BA），并与单一有机溴和微囊藻毒素LR暴露进行比较。在某些生活性状变量中观察到刺激效应，这在接触MC-BA的线虫中特别明显。全基因组DNA微阵列显示，MC-BA导致超过2000个基因的差异表达，其中许多已知参与代谢，神经和形态学过程。此外，cyp-基因的上调和abu-基因的下调提示慢性应激的存在。然而，线虫没有表现出阴性表型反应。假设MC-BA和微囊藻毒素-LR（影响寿命、生长和繁殖）暴露线虫中观察到的差异可能是由于分批培养中的其他化合物所致。最有可能的是，接触低浓度的有机溴似乎可以缓冲有毒物质的影响，如微囊藻毒素-LR。
Elevated levels of adsorbable organic bromine compounds (AOBr) have been detected in German lakes, and cyanobacteria likeMicrocystis, which are known for the synthesis of microcystins, are one of the main producers of natural organobromines. However, very little is known about how environmental realistic concentrations of organobromines impact invertebrates. Here, the nematodeCaenorhabditis eleganswas exposed to AOBr-containing surface water samples and to aMicrocystis aeruginosa-enriched batch culture (MC-BA) and compared to single organobromines and microcystin-LR exposures. Stimulatory effects were observed in certain life trait variables, which were particularly pronounced in nematodes exposed to MC-BA. A whole genome DNA-microarray revealed that MC-BA led to the differential expression of more than 2000 genes, many of which are known to be involved in metabolic, neurologic, and morphologic processes. Moreover, the upregulation ofcyp- and the downregulation ofabu-genes suggested the presence of chronic stress. However, the nematodes were not marked by negative phenotypic responses. The observed difference in MC-BA and microcystin-LR (which impacted lifespan, growth, and reproduction) exposed nematodes was hypothesized to be likely due to other compounds within the batch culture. Most likely, the exposure to low concentrations of organobromines appears to buffer the effects of toxic substances, like microcystin-LR.
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DOI：
10.1039/9781847558428
发表时间：
2008
期刊：
--
影响因子：
--
作者：
C. Ioannides
通讯作者：
C. Ioannides
通过秀丽隐杆线虫测试对两种有机溴模型化合物和天然含 AOBr 地表水样进行神经毒性评估
影响因子：
6.8
作者：
Ju, Jingjuan;Lieke, Thora;Steinberg, Christian E. W.
通讯作者：
Steinberg, Christian E. W.
影响因子：
7.3
作者：
FULLER, RW;CARDELLINA, JH;BOYD, MR
通讯作者：
BOYD, MR
上层结构中的教育组织和超滤研究
DOI：
--
发表时间：
2007
期刊：
影响因子：
--
作者：
A. Hütteroth
通讯作者：
A. Hütteroth
影响因子：
4.1
作者：
Höss, S;Haitzer, M;Steinberg, CEW
通讯作者：
Steinberg, CEW