On the biomechanics of heart valve function.
On the biomechanics of heart valve function.
复制标题
DOI：
10.1016/j.jbiomech.2009.05.015
复制
发表时间：
2009-08-25
影响因子：
2.4
通讯作者：
Schmidt, David E.
中科院分区：
文献类型：
--
作者：
Sacks, Michael S.;Merryman, W. David;Schmidt, David E.
心脏瓣膜(HV)是心脏的流体控制组件，确保心脏循环期间的单向血液流动。然而，这种描述没有充分描述它们的功能的生物力学分支，因为它们的力学是多模式的。此外，它们必须在整个生命周期内重复其循环功能，估计总功能需求至少为3×109个循环。本综述的重点是心脏瓣膜的功能生物力学。因此，本综述的重点是功能生物力学，主要涉及生物固体以及心脏瓣膜生理功能的几个关键生物流体力学方面。具体地说，我们指的是细胞外基质结构蛋白的力学行为，潜在的细胞功能，以及它们与瓣膜血流动力学主要方面的综合关系。虽然我们专注于提交人的实验室的工作，但在适当的时候也包括了其他调查人员的相关工作。最后，我们总结了未来的重要趋势。
Heart valves (HVs) are fluidic control components of the heart that ensure unidirectional blood flow during the cardiac cycle. However, this description does not adequately describe the biomechanical ramifications of their function in that their mechanics are multi-modal. Moreover, they must replicate their cyclic function over an entire lifetime, with an estimated total functional demand of least 3×109 cycles. The focus of the present review is on the functional biomechanics of heart valves. Thus, the focus of the present review is on functional biomechanics, referring primarily to biosolid as well as several key biofluid mechanical aspects underlying heart valve physiological function. Specifically, we refer to the mechanical behaviors of the extra-cellular matrix structural proteins, underlying cellular function, and their integrated relation to the major aspects of valvular hemodynamic function. While we focus on the work from the author’s laboratories, relevant works of other investigators have been included whenever appropriate. We conclude with a summary of important future trends.
登录
查看更多内容
DOI：
10.1115/1.1318906
发表时间：
2000-12-01
影响因子：
1.7
作者：
Butler, DL;Goldstein, SA;Guilak, F
通讯作者：
Guilak, F
影响因子：
37.8
作者：
Aikawa, E;Whittaker, P;Schoen, FJ
通讯作者：
Schoen, FJ
影响因子：
14
作者：
Engelmayr, GC;Hildebrand, DK;Sacks, MS
通讯作者：
Sacks, MS
影响因子：
2.4
作者：
De Hart, J;Peters, GWM;Baaijens, FPT
通讯作者：
Baaijens, FPT
影响因子：
2.4
作者：
BROSSOLLET, LJ;VITO, RP
通讯作者：
VITO, RP