Mechanochemical control of mesenchymal condensation and embryonic tooth organ formation.
Mechanochemical control of mesenchymal condensation and embryonic tooth organ formation.
复制标题
间充质凝结和胚胎齿器官形成的机械化学控制。
DOI：
10.1016/j.devcel.2011.07.006
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发表时间：
2011-10-18
影响因子：
11.8
通讯作者：
Ingber, Donald E.
中科院分区：
文献类型：
--
作者：
Mammoto, Tadanori;Mammoto, Akiko;Torisawa, Yu-suke;Tat, Tracy;Gibbs, Ashley;Derda, Ratmir;Mannix, Robert;de Bruijn, Marlieke;Yung, Chong Wing;Huh, Dongeun;Ingber, Donald E.
Mesenchymal condensation is critical for organogenesis, yet little is known about how this process is controlled. Here we show that Fgf8 and Sema3f produced by early dental epithelium respectively attract and repulse mesenchymal cells, which causes them to pack tightly together during mouse tooth development. Resulting mechanical compaction-induced changes in cell shape induce odontogenic transcription factors (Pax9, Msx1) and chemical cue (BMP4), and mechanical compression of mesenchyme is sufficient to induce tooth-specific cell fate switching. The inductive effects of cell compaction are mediated by suppression of the mechanical signaling molecule RhoA, and its over-expression prevents odontogenic induction. Thus, the mesenchymal condensation that drives tooth formation is induced by antagonistic epithelial morphogens that manifest their pattern-generating actions mechanically via changes in mesenchymal cell shape and altered mechanotransduction.
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影响因子：
64.8
作者：
Mammoto, Akiko;Connor, Kip M.;Mammoto, Tadanori;Yung, Chong Wing;Huh, Dongeun;Aderman, Christopher M.;Mostoslavsky, Gustavo;Smith, Lois E. H.;Ingber, Donald E.
通讯作者：
Ingber, Donald E.
DOI：
10.1098/rspb.2004.2772
发表时间：
2004-08-22
影响因子：
4.7
作者：
Hentschel, HGE;Glimm, T;Newman, SA
通讯作者：
Newman, SA
影响因子：
2.7
作者：
Grima, Ramon;Schnell, Santiago
通讯作者：
Schnell, Santiago
影响因子：
2.7
作者：
KNUDSON, CB;TOOLE, BP
通讯作者：
TOOLE, BP
影响因子：
1.5
作者：
Gratsch, TE;De Boer, LS;O'Shea, KS
通讯作者：
O'Shea, KS