DAF-2 and ERK couple nutrient availability to meiotic progression during Caenorhabditis elegans oogenesis.
DAF-2 and ERK couple nutrient availability to meiotic progression during Caenorhabditis elegans oogenesis.
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DOI：
10.1016/j.devcel.2013.09.008
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发表时间：
2013-10-28
影响因子：
11.8
通讯作者：
Arur, Swathi
中科院分区：
文献类型：
--
作者：
Lopez, Andrew L., III;Chen, Jessica;Joo, Hyoe-Jin;Drake, Melanie;Shidate, Miri;Kseib, Cedric;Arur, Swathi
Coupling the production of mature gametes and fertilized zygotes to favorable nutritional conditions improves reproductive success. In invertebrates, the proliferation of female germ line stem cells is regulated by nutritional status. But, in mammals the number of female germ line stem cells is set early in development, with oocytes progressing through meiosis later in life. Mechanisms that couple later steps of oogenesis to environmental conditions remain largely undefined. We show that in the presence of food, the DAF-2 insulin-like receptor signals through the RAS-ERK pathway to drive meiotic prophase I progression and oogenesis; in the absence of food, the resultant inactivation of insulin-like signaling leads to downregulation of RAS-ERK pathway, and oogenesis is stalled. Thus, the insulin-like signaling pathway couples nutrient sensing to meiotic I progression and oocyte production in C. elegans, ensuring that oocytes are only produced under conditions favorable for the survival of the resulting zygotes.
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