The microbiology of diabetic foot infections: a meta-analysis.
The microbiology of diabetic foot infections: a meta-analysis.
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DOI：
10.1186/s12879-021-06516-7
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发表时间：
2021-08-09
影响因子：
3.7
通讯作者：
Jones JD
中科院分区：
文献类型：
--
作者：
Macdonald KE;Boeckh S;Stacey HJ;Jones JD
糖尿病足溃疡是糖尿病控制不佳的常见并发症，并且经常被感染，称为糖尿病足感染。关于糖尿病足感染的微生物学已有大量研究，但没有荟萃分析提供这些数据的全球概述。这项荟萃分析旨在利用报告糖尿病足感染培养结果的任何设计研究来调查从糖尿病足感染中分离出的细菌的流行率。在 Medline、EMBASE、Web of Science 和 BIOSIS 电子数据库中检索了截至 2019 年发表的研究，其中包含至少 10 名糖尿病足感染患者的微生物培养结果。两位作者独立评估研究资格并提取数据。主要结果是每个细菌属或物种的流行率。总共纳入了 112 项研究，涉及 16,159 名患者，从中获得了 22,198 株微生物分离株。最常见的微生物是金黄色葡萄球菌，其中 18.0% (95% CI 13.8–22.6%; I2 = 93.8% [93.0–94.5%]) 是 MRSA。其他高度流行的生物体包括假单胞菌属、大肠杆菌和肠球菌属。国民总收入与糖尿病足感染中革兰氏阳性或阴性微生物的流行率之间存在相关性。糖尿病足感染的微生物学多种多样，但金黄色葡萄球菌占主导地位。革兰氏阳性菌和阴性菌的患病率与国民总收入之间的相关性可以反映医疗保健提供和卫生设施的差异。这项荟萃分析综合了多个数据集，以提供糖尿病足感染微生物学的全球概述，这将有助于指导新疗法的开发。在线版本包含可在 10.1186/s12879-021-06516-7 获取的补充材料。
Diabetic foot ulcers are a common complication of poorly controlled diabetes and often become infected, termed diabetic foot infection. There have been numerous studies of the microbiology of diabetic foot infection but no meta-analysis has provided a global overview of these data. This meta-analysis aimed to investigate the prevalence of bacteria isolated from diabetic foot infections using studies of any design which reported diabetic foot infection culture results. The Medline, EMBASE, Web of Science and BIOSIS electronic databases were searched for studies published up to 2019 which contained microbiological culture results from at least 10 diabetic foot infection patients. Two authors independently assessed study eligibility and extracted the data. The main outcome was the prevalence of each bacterial genera or species. A total of 112 studies were included, representing 16,159 patients from which 22,198 microbial isolates were obtained. The organism most commonly identified was Staphylococcus aureus, of which 18.0% (95% CI 13.8–22.6%; I2 = 93.8% [93.0–94.5%]) was MRSA. Other highly prevalent organisms were Pseudomonas spp., E. coli and Enterococcus spp. A correlation was identified between Gross National Income and the prevalence of Gram positive or negative organisms in diabetic foot infections. The microbiology of diabetic foot infections is diverse, but S. aureus predominates. The correlation between the prevalence of Gram positive and negative organisms and Gross National Income could reflect differences in healthcare provision and sanitation. This meta-analysis has synthesised multiple datasets to provide a global overview of the microbiology of diabetic foot infections that will help direct the development of novel therapeutics. The online version contains supplementary material available at 10.1186/s12879-021-06516-7.
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