Body mass index and risk of stroke among Chinese men and women.
Body mass index and risk of stroke among Chinese men and women.
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DOI：
10.1002/ana.21950
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发表时间：
2010-01
影响因子：
11.2
通讯作者：
He, Jiang
中科院分区：
文献类型：
--
作者：
Bazzano, Lydia A.;Gu, Dongfeng;Whelton, Megan R.;Wu, Xiqui;Chen, Chung-Shluan;Duan, Xiufang;Chen, Jing;Chen, Ji-chun;He, Jiang
体重指数（BMI）与卒中发病率和死亡率之间的关系仍存在争议，特别是在亚洲人群中。我们对169，871名40岁或以上的中国男性和女性进行了一项具有全国代表性的前瞻性队列研究。1991年采用标准方案进行基线检查时获得了体重数据。1999年至2000年进行了跟踪评估，回应率为93.4%。在排除了那些体重或身高值缺失的参与者后，154，736名成年人被纳入分析。在平均8.3年的随访期间，发生了7，489例中风（3，924例死亡）。在调整了年龄、性别、身体不活动、城市化、地理差异、吸烟、糖尿病和教育之后，与正常体重的参与者相比，（BMI 18.5-24.9），相对风险卒中发生率（95%置信区间）为0.86（0.80-0.93）体重不足的参与者体重指数< 18.5者为1.43（1.36-1.52），超重者（体重指数25-29.9）为1.43（1.36-1.52），肥胖者（体重指数≥ 30）为1.72（1.55-1.91）。缺血性卒中的相应相对风险分别为0.76（0.66-0.86）、1.60（1.48-1.72）和1.89（1.66-2.16），出血性卒中的相应相对风险分别为1.00（0.89-1.13）、1.18（1.06-1.31）和1.54（1.27-1.87）。对于卒中死亡率，相应的相对危险度分别为0.94（0.86-1.03）、1.15（1.05-1.25）和1.47（1.26-1.72）。所有结果的线性趋势均具有显著性（p < 0.0001）。这些结果表明，在中国成年人中，BMI升高会增加缺血性和出血性卒中的发病率以及卒中死亡率。
The relationship between body mass index (BMI) and stroke incidence and mortality remains controversial, particularly in Asian populations. We conducted a prospective cohort study in a nationally representative sample of 169,871 Chinese men and women age 40 years or older. Data on body weight was obtained at baseline examination in 1991 using a standard protocol. Follow-up evaluation was conducted in 1999 to 2000, with a response rate of 93.4%. After excluding those participants with missing body weight or height values, 154,736 adults were included in the analysis. During a mean follow-up of 8.3 years, 7,489 strokes occurred (3,924 fatal). After adjustment for age, gender, physical inactivity, urbanization, geographic variation, cigarette smoking, diabetes, and education, compared with participants of normal weight (BMI 18.5–24.9), relative hazard (95% confidence interval) of incident stroke was 0.86 (0.80–0.93) for participants who were underweight (BMI < 18.5), 1.43 (1.36–1.52) for those who were overweight (BMI 25–29.9), and 1.72 (1.55–1.91) for those who were obese (BMI ≥ 30). The corresponding relative hazards were 0.76 (0.66–0.86), 1.60 (1.48–1.72), and 1.89 (1.66–2.16) for ischemic stroke and 1.00 (0.89–1.13), 1.18 (1.06–1.31), and 1.54 (1.27–1.87) for hemorrhagic stroke. For stroke mortality, the corresponding relative hazards were 0.94 (0.86–1.03), 1.15 (1.05–1.25), and 1.47 (1.26–1.72). Linear trends were significant for all outcomes (p < 0.0001). These results suggest that elevated BMI increases the risk of both ischemic and hemorrhagic stroke incidence, and stroke mortality in Chinese adults.
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影响因子：
8.3
作者：
HARMSEN, P;ROSENGREN, A;WILHELMSEN, L
通讯作者：
WILHELMSEN, L
影响因子：
8.3
作者：
Rosamond, WD;Folsom, AR;Shahar, E
通讯作者：
Shahar, E
影响因子：
8.3
作者：
Harmsen, Per;Lappas, Georg;Wilhelmsen, Lars
通讯作者：
Wilhelmsen, Lars
影响因子：
8.3
作者：
HAHEIM, LL;HOLME, I;LEREN, P
通讯作者：
LEREN, P
影响因子：
37.8
作者：
Kurth, T;Gaziano, JM;Buring, JE
通讯作者：
Buring, JE